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. 2020 Aug 8;40(4):603–614. doi: 10.1016/j.cll.2020.08.014

Fig. 4.

Fig. 4

Conservation of surface amino acids between SARS-CoV-2, SARS-CoV-1, and CoV-OC43: (A) space-filling model of the NP protein RNA-binding region (PDB [Protein Data Bank] 6M3M) and dimerization region (PDB 2GIB) from SARS-CoV-1 with sequence conservation mapped on the surface projection from ClustalW alignments between SARS-CoV-1 (NCBI BAE93401), SARS-CoV-2 (NCBI YP_009724390), and CoV-OC43 (NCBI YP_009555245). (B) Space-filling model of the full-length SARS-CoV-2 S protein monomer (PDB CVYB) with sequence conservation mapped on the surface projection from ClustalW alignments from SARS-CoV-2 (NCBI YP_009724390), SARS-CoV-1 (NCBI BAE93401), and CoV-OC43 (NCBI YP_009555241).