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. 2020 Aug 8;30(20):127472. doi: 10.1016/j.bmcl.2020.127472

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Scheme 1 — Synthesis of 6-substituted 4-anilinoquinazoline derivatives. Reagents and conditions: (a) DMF-DMA, toluene, 110 °C, 5 h; (b) ArNH₂, AcOH, 120 °C, 7 h; (c) Fe, NH₄Cl, i-PrOH/H₂O (10/1), 110 °C/4h; (d) Aldehyde, NaBH(OAc)₃, trifluoroacetic acid, i-PrOAc, 90 °C, 3 h; Acyl chloride, Et₃N, dichloromethane, rt; or carboxylic acid, EDCI, i-Pr₂NEt, DMF, rt.