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Antiviral effect and toxicity of 4-anilino groups of hit compound 1.
| Compound | Y | IC50(μM)a | CC50(μM)b | SIc |
|---|---|---|---|---|
| 1 | 3-Cl,4-F | 5.6 | >25 | 4.5 |
| 6 | 4-Br | 7.4 | >25 | 3.4 |
| 7 | 4-F | 22.7 | >25 | 1.1 |
| 8 | 3-Cl | >25 | 23.0 | 1.0 |
| 9 | 4-CN | >25 | >25 | 1.0 |
| 10 | 3-COCH3 | >25 | >25 | 1.0 |
| 11 | 4-CF3 | 1.8 | >25 | 1.0 |
IC50 and CC50 were derived from the results of at least two dependent experiment in Vero cells infected with MERS-CoV.
SI(selective index) = CC50/IC50 for inhibiting MERS-CoV infection.
