Table 3.
Result of hERG, Microsomal stability, cytotoxicity of 20.
| Compound | hERG (μM) | MSa |
Cytotoxicity (μM)b |
|||||
|---|---|---|---|---|---|---|---|---|
| ma | ha | Veroc | HFL-1 | L929 | NIH 3T3 | CHO-K1 | ||
| 20 | >50 | 60.7 | 56.4 | >100 | >100 | >100 | >100 | >100 |
a
% original compound remained after 30 min incubation.
b
Cell information. Vero: African green monkey kidney cell line, HFL-1: human embryonic lung cell line, L929: NCTC clone 929, mouse fibroblast cell line, NIH 3T3: mouse embryonic fibroblast cell line, CHO-K1: Chinese hamster ovary cell line.
c
Vero cell was not infected with MERS-CoV.