Table 10.

Effect of oral administration of GMCT on biochemical parameters in female Wistar rats.

Parameters	Primary groups Dose (mg/kg/day)				Reversal groups Dose (mg/kg/day)
	0 (G1)	250 (G2)	500 (G3)	1000 (G4)	0 (G1R)	1000 (G4R)
Glu (mg/dL)	110.60 ± 10.48	107.80 ± 7.46	99.80 ± 8.76	109.00 ± 10.95	102.40 ± 5.03	118.0 ± 13.32#
BUN (mg/dL)	17.80 ± 0.45	19.60 ± 4.51	21.40 ± 3.91	19.40 ± 2.70	18.80 ± 2.05	20.80 ± 2.17
Ur (mg/dL)	38.80 ± 1.10	42.00 ± 9.14	45.60 ± 8.32	41.60 ± 6.19	40.00 ± 3.94	44.40 ± 4.39
Crea (mg/dL)	0.54 ± 0.04	0.55 ± 0.04	0.52 ± 0.06	0.55 ± 0.05	0.54 ± 0.04	0.55 ± 0.08
T.Chol (mg/dL)	38.20 ± 7.92	39.20 ± 10.26	37.80 ± 7.29	41.80 ± 4.97	35.00 ± 6.40	48.00 ± 7.04#
Trig (mg/dL)	79.60 ± 66.59	91.80 ± 63.38	58.20 ± 13.14	65.80 ± 22.59	77.20 ± 32.48	82.60 ± 34.96
T.Bil (mg/dL)	0.06 ± 0.03	0.05 ± 0.03	0.05 ± 0.04	0.09 ± 0.03	0.11 ± 0.02	0.10 ± 0.05
AST (U/L)$	80.00 ± 4.95	96.60 ± 6.47∗	90.20 ± 7.19∗	81.20 ± 5.72	89.00 ± 9.35	95.80 ± 25.79
ALT (U/L)$	31.40 ± 1.95	35.40 ± 5.18	39.4 ± 4.93	46.00 ± 11.11∗	38.80 ± 6.83	35.20 ± 8.26
ALP (U/L)	39.80 ± 8.76	49.00 ± 15.73	41.00 ± 5.70	47.40 ± 13.74	37.40 ± 16.32	36.20 ± 14.31
TP (g/dL)	6.79 ± 0.22	6.82 ± 0.40	6.66 ± 0.38	6.80 ± 0.29	6.98 ± 0.19	7.18 ± 0.27
Alb (g/dL)	4.38 ± 0.15	4.28 ± 0.19	4.28 ± 0.27	4.34 ± 0.26	4.30 ± 0.14	4.24 ± 0.28
Ca (mg/dL)	10.56 ± 0.25	10.10 ± 0.19	10.20 ± 0.21	10.38 ± 0.49	10.48 ± 0.13	10.44 ± 0.17
Phos (mg/dL)	4.88 ± 0.50	4.46 ± 0.23	5.30 ± 0.52	5.16 ± 0.29	4.16 ± 0.48	4.68 ± 0.66
Na (mmoL/L)	141.16 ± 1.03	141.74 ± 0.65	140.44 ± 0.96	141.46 ± 1.02	141.70 ± 0.69	141.74 ± 0.65
K (mmoL/L)	3.50 ± 0.28	3.37 ± 0.15	3.65 ± 0.19	3.54 ± 0.15	3.52 ± 0.20	3.59 ± 0.17
Cl (mmoL/L)	105.54 ± 1.33	105.82 ± 0.79	104.04 ± 0.91	105.54 ± 1.16	106.24 ± 0.91	105.54 ± 1.77

Data are present as mean ± SD; n = 5. ^∗ and #Significance p < 0.05 vs. G1 and G1R, respectively. ^$The mean ± SD of the historical values of AST is 107.75 ± 33.30 U/L (min. 70.0 U/L; max. 167.0 U/L) and ALT is 41.47 ± 9.08 U/L (min. 25.0 U/L; 67.0 U/L).