Table 14.
Effect of GMCT supplementation on micronucleus frequency in mouse bone marrow erythrocytes.
| Treatments | Dose (mg/kg) | Male (n = 5) | Female (n = 5) | ||
|---|---|---|---|---|---|
| PCE : TE | % MNPCE | PCE : TE | % MNPCE | ||
| Vehicle control | 0 | 0.642 ± 0.038 | 0.080 ± 0.048 | 0.591 ± 0.021 | 0.110 ± 0.058 |
| GMCT | 500 | 0.625 ± 0.036 | 0.0035 ± 0.034 | 0.595 ± 0.041 | 0.025 ± 0.035 |
| GMCT | 1,000 | 0.612 ± 0.030 | 0.020 ± 0.033 | 0.616 ± 0.025 | 0.040 ± 0.038 |
| GMCT | 2,000 | 0.600 ± 0.032 | 0.015 ± 0.022 | 0.616 ± 0.029 | 0.020 ± 0.027 |
| Cyclophosphamide monohydrate | 40 | 0.618 ± 0.045 | 1.900 ± 0.083∗ | 0.612 ± 0.038 | 1.910 ± 0.068∗ |
Data are present as mean ± SD; ∗p < 0.05, comparison between treatment and control groups in one-way ANOVA. MNPCE = micronucleated polychromatic erythrocyte; PCE = polychromatic erythrocytes; TE = total erythrocytes.