Table 8.

Effect of oral administration of GMCT on hematology parameters in female Wistar rats.

Parameters	Primary groups Dose (mg/kg/day)				Reversal groups Dose (mg/kg/day)
	0 (G1)	250 (G2)	500 (G3)	1000 (G4)	0 (G1R)	1000 (G4R)
RBC (106/μL)	8.70 ± 0.35	8.81 ± 0.47	8.56 ± 0.34	8.94 ± 0.29	8.67 ± 0.55	8.75 ± 0.24
Hb (g/dL)	15.64 ± 0.97	15.78 ± 0.65	15.62 ± 0.74	15.86 ± 0.53	15.62 ± 0.91	15.66 ± 0.35
Hct (%)	47.62 ± 2.86	47.96 ± 1.25	46.82 ± 2.33	48.66 ± 1.29	47.94 ± 2.84	48.70 ± 1.03
MCV (fL)	54.7 ± 1.20	54.52 ± 2.09	54.64 ± 1.52	54.46 ± 0.99	55.30 ± 1.02	55.66 ± 0.55
MCH (pg)	17.96 ± 0.42	17.94 ± 0.48	18.22 ± 0.40	17.76 ± 0.54	18.02 ± 0.24	17.90 ± 0.51
MCHC (g/dL)	32.82 ± 0.29	32.90 ± 0.94	33.36 ± 1.03	32.62 ± 0.43	32.58 ± 0.28	32.12 ± 0.90
Plt (103/μL)	929.00 ± 46.69	806.20 ± 56.4	810.60 ± 314.78	1000.40 ± 136.02	834.80 ± 112.17	915.80 ± 102.40
WBC (103/μL)	5.32 ± 0.78	4.55 ± 1.15	5.24 ± 1.20	5.61 ± 1.20	4.85 ± 0.84	5.68 ± 1.68
Neu (%)	11.30 ± 1.77	20.82 ± 7.44	18.52 ± 12.38	12.92 ± 3.39	13.66 ± 4.42	12.38 ± 2.82
Lym (%)	84.10 ± 1.66	74.26 ± 8.23	75.96 ± 12.82	82.32 ± 3.21	81.24 ± 4.76	82.68 ± 2.88
Mono (%)	1.84 ± 0.31	2.48 ± 0.96	2.48 ± 0.50	2.20 ± 0.42	2.26 ± 0.65	2.26 ± 0.30
Eos (%)	1.98 ± 0.31	1.60 ± 0.44	2.18 ± 0.87	1.26 ± 0.23	1.74 ± 0.78	1.52 ± 0.51
Baso (%)	0.26 ± 0.09	0.24 ± 0.05	0.28 ± 0.13	0.30 ± 0.10	0.34 ± 0.09	0.28 ± 0.16
LUC (%)$	0.52 ± 0.16	0.60 ± 0.10	0.64 ± 0.11	1.00 ± 0.33∗	0.76 ± 0.35	0.92 ± 0.43
Rec (%)	2.32 ± 0.11	2.04 ± 0.17	2.16 ± 0.26	2.46 ± 0.38	2.50 ± 0.40	2.28 ± 0.23
CT (sec)	136.60 ± 25.55	144.60 ± 21.07	146.00 ± 13.80	142.60 ± 32.55	118.00 ± 14.58	122.60 ± 9.29

Data are present as mean ± SD; n = 5. ^∗p < 0.05 vs. G1. ^$The mean ± SD of the historical normal values (%) of large unstained cells (LUC) is 1.20 ± 0.6 (min. 0.3%; max. 4.0%).