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. Author manuscript; available in PMC: 2020 Aug 8.
Published in final edited form as: Appl Mater Today. 2019 Oct 9;18:100479. doi: 10.1016/j.apmt.2019.100479

Fig. 6. Fabrication of bio/synthetic interpenetrating network.

Fig. 6.

(BioSIN) of (a) Gelatin methacrylamide and poly(ethylene glycol) via concurrent photoinitiation of thiol-ene and thiolyne coupling. The click-functionalized macromer precursors undergo multi-mode crosslinking to form an interlocking 3D hydrogel; (b) The well-defined network architecture of TYC-formed PEG hydrogels were intertwined with either; (c) Physically-incorporated gelatin (BioSINP) or; (d) Covalently crosslinked gelatin methacrylamide (BioSINx) in which the gelatin methacrylamide reacts with both itself and the PEG network.; (e) The architectural heterogeneity emulated native extracellular matrix; (f) Superior physiochemical properties were able to support the continued proliferation of encapsulated cells, where cytoskeletal F-actin fiber staining illustrates the density and interaction of encapsulated cells [150] with permission from Elsevier, copyright 2014.