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Selection of NA 151 variants in viruses bearing an H150 or R150 NA paired with an older or more modern HA. RG viruses were generated and passaged twice in duplicate at 0.01p.f.u./cell in MDCK-SIAT1 cell before sequencing by NGS. D151G/N variants were selected in both viruses with the H150 NA and R150 NA. The older Wisconsin/2005 HA was unable to drive selection of NA 151 variants in the Sydney/2014 NA. No minor variants were detected at 148 or 150 of NA.
