Table 2.
Panel of influenza A/H3N2 isolates with HA titres sensitive to oseltamivir. HA assays were conducted on n=38 cell-passaged isolates from 2013–162013-2016 in the presence or absence of 40 nM oseltamivir and those with the greatest titre reductions are recorded here. Passage level indicates the number of passages the isolate had undergone in MDCK and/or MDCK-SIAT1 cells prior to titration
|
HA titre |
||||||
|---|---|---|---|---|---|---|
|
Strain |
Subtype |
Clade |
Passage level |
Without oseltamivir |
With oseltamivir |
Fold drop in the presence of oseltamivir |
|
A/Alaska/232/2016 |
H3N2 |
3C.2a1 |
SIAT5 |
16 |
0 |
total |
|
A/Canberra/7/2016 |
H3N2 |
3C.2a |
SIAT4 |
16 |
0 |
total |
|
A/Hong Kong/4801/2014 |
H3N2 |
3C.2a |
MDCK4SIAT3 |
16 |
0 |
total |
|
A/South Australia/21/2015 |
H3N2 |
3C.2a |
SIAT4 |
32 |
0 |
total |
|
A/Switzerland/9715293/2013 |
H3N2 |
3C.3a |
SIAT3MDCK2SIAT1 |
128 |
32 |
4 |
|
A/Sydney/71/2014 |
H3N2 |
3C.2a |
MDCK4SIAT1 |
64 |
16 |
4 |
|
A/Yokohama/120/2016 |
H3N2 |
3C.2a |
MDCK1SIAT3 |
16 |
2 |
8 |