Figure 1.

Histopathologic evaluation in bone marrow clot. A. (scanning, H&E) Bone marrow clot. At least five spikes are required to ensure sample representativeness. Note the increased global cellularity. B and C. (400×, H&E) Megaloblasts in the context of granulocytic hypercellularity. D. (400×, H&E) Cellular gigantism of the granulocytic series demonstrated by a metamyelocyte. The cell under analysis is circled in yellow. E. (200×, Perls) Exemplification of a patient without iron deficiency. The hemosiderin deposits are stained blue. F. (Reticulin, 400×) Case example with grade 2 reticulin.