Table 3.
Association analysis of the COMT rs4680 allele, genotype frequencies, and the response rate with patients treated with different drugs in the case group
| COMT rs4680 | Number | Allele (%) | statistics | Genotype (%) | statistics | |||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| A | G | AA | AG | GG | ||||
| Response | ||||||||
| Responsive | 60 | 45 (37.5) | 75 (62.5) | χ2=0.390 | 9 (15.0) | 27 (45.0) | 24 (40.0) | χ2=0.574 |
| Nonresponsive | 42 | 36 (42.9) | 48 (57.1) | P=0.470 | 8 (19.0) | 20 (47.6) | 14 (33.3) | P=0.750 |
| Remission | ||||||||
| Remitter | 36 | 32 (44.4) | 40 (55.6) | χ2=1.044 | 7 (19.4) | 18 (50.0) | 11 (30.6) | χ2=1.114 |
| Nonremitter | 66 | 49 (37.1) | 83 (62.9) | P=0.369 | 10 (15.2) | 29 (43.9) | 27 (40.9) | P=0.573 |
| Escitalopram | ||||||||
| Responsive | 35 | 30 (42.9) | 40 (57.1) | χ2=0.027 | 7 (20.0) | 16 (45.7) | 12 (34.3) | χ2=0.126 |
| Nonresponsive | 24 | 19 (39.6) | 29 (60.4) | P=0.849 | 4 (16.7) | 11 (45.8) | 9 (37.5) | P=0.939 |
| Remitter | 20 | 18 (45.0) | 22 (55.0) | χ2=0.123 | 3 (10.0) | 12 (40.0) | 5 (16.7) | χ2=2.510 |
| Nonremitter | 39 | 31 (39.7) | 47 (60.3) | P=0.694 | 8 (20.5) | 15 (38.5) | 16 (41.0) | P=0.285 |
| Venlafaxine | ||||||||
| Responsive | 25 | 15 (30.0) | 35 (70.0) | χ2=2.657 | 2 (8.0) | 11 (44.0) | 12 (48.0) | χ2=1.163 |
| Nonresponsive | 18 | 17 (47.2) | 19 (52.8) | P=0.118 | 4 (22.2) | 9 (50.0) | 5 (27.8) | P=0.559 |
| Remitter | 16 | 14 (43.8) | 18 (56.2) | χ2=0.933 | 4 (25.0) | 6 (37.5) | 6 (37.5) | χ2=2.700 |
| Nonremitter | 27 | 18 (33.3) | 36 (66.7) | P=0.364 | 2 (7.4) | 14 (51.9) | 11 (40.7) | P=0.259 |
Note. COMT, Catechol-O-methyltransferase; χ2 Test.