Table 2.
Genotype distribution and allele frequency of HSG polymorphisms in the case and control groups
| SNP | Genotype (frequency, %) | P* | Allele (frequency, %) | P** | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| rs873457 | CC | CG | GG | C | G | |||||
| Total | Case | 86 (21.4) | 219 (54.5) | 97 (24.1) | Case | 391 (48.6) | 413 (51.4) | |||
| Control | 53 (19.9) | 123 (46.1) | 91 (34.1) | 0.018 | Control | 229 (42.9) | 305 (57.1) | 0.039 | ||
| Male | Case | 65 (22.7) | 157 (54.9) | 64 (22.4) | Case | 287 (50.2) | 285 (49.8) | |||
| Control | 27 (15.5) | 87 (50.0) | 60 (34.5) | 0.010 | Control | 141 (40.5) | 207 (59.5) | 0.004 | ||
| Female | Case | 21 (18.1) | 62 (53.4) | 33 (28.4) | Case | 104 (44.8) | 128 (55.2) | |||
| Control | 26 (28.0) | 36 (38.7) | 31 (33.3) | 0.081 | Control | 88 (47.3) | 98 (52.7) | 0.613 | ||
| rs2236384 | GG | GT | TT | G | T | |||||
| Total | Case | 87 (21.6) | 219 (54.5) | 96 (23.9) | Case | 393 (48.9) | 411 (51.1) | |||
| Control | 53 (19.9) | 123 (46.1) | 91 (34.1) | 0.015 | Control | 229 (42.9) | 305 (57.1) | 0.031 | ||
| Male | Case | 66 (23.1) | 156 (54.5) | 64 (22.4) | Case | 288 (50.3) | 284 (49.7) | |||
| Control | 27 (15.5) | 87 (50.0) | 60 (34.5) | 0.009 | Control | 141 (40.5) | 207 (59.5) | 0.004 | ||
| Female | Case | 21 (18.1) | 63 (54.3) | 32 (27.6) | Case | 105 (45.3) | 127 (54.7) | |||
| Control | 26 (28.0) | 36 (38.7) | 31 (33.3) | 0.065 | Control | 88 (47.3) | 98 (52.7) | 0.675 | ||
| rs2295281 | CC | CT | TT | C | T | |||||
| Total | Case | 48 (11.9) | 192 (47.8) | 162 (40.3) | Case | 288 (35.8) | 516 (64.2) | |||
| Control | 48 (18.0) | 115 (43.1) | 104 (39.0) | 0.085 | Control | 211 (39.5) | 323 (60.5) | 0.171 | ||
| Male | Case | 32 (11.2) | 133 (46.5) | 121 (42.3) | Case | 197 (34.4) | 375 (65.6) | |||
| Control | 33 (19.0) | 80 (46.0) | 61 (35.1) | 0.047 | Control | 146 (42.0) | 202 (58.0) | 0.022 | ||
| Female | Case | 16 (13.8) | 59 (50.9) | 41 (35.3) | Case | 91 (39.2) | 141 (60.8) | |||
| Control | 15 (16.1) | 35 (37.6) | 43 (46.2) | 0.156 | Control | 65 (34.9) | 121 (65.1) | 0.368 | ||
| rs4846085 | CC | CT | TT | C | T | |||||
| Total | Case | 98 (24.4) | 217 (54.0) | 87 (21.6) | Case | 413 (51.4) | 391 (48.6) | |||
| Control | 91 (34.1) | 122 (45.7) | 54 (20.2) | 0.021 | Control | 304 (56.9) | 230 (43.1) | 0.046 | ||
| Male | Case | 65 (22.7) | 155 (54.2) | 66 (23.1) | Case | 285 (49.8) | 287 (50.2) | |||
| Control | 60 (34.5) | 86 (49.4) | 28 (16.1) | 0.014 | Control | 206 (59.2) | 142 (40.8) | 0.005 | ||
| Female | Case | 33 (28.4) | 62 (53.4) | 21 (18.1) | Case | 128 (55.2) | 104 (44.8) | |||
| Control | 31 (33.3) | 36 (38.7) | 26 (28.0) | 0.081 | Control | 98 (52.7) | 88 (47.3) | 0.613 | ||
| rs1474868 | CC | CT | TT | C | T | |||||
| Total | Case | 118 (29.4) | 207 (51.5) | 77 (19.2) | Case | 433 (55.1) | 361 (44.9) | |||
| Control | 104 (39.0) | 117 (43.8) | 46 (17.2) | 0.035 | Control | 325 (60.9) | 209 (39.1) | 0.037 | ||
| Male | Case | 77 (26.9) | 150 (52.4) | 59 (20.6) | Case | 304 (53.1) | 268 (46.9) | |||
| Control | 67 (38.5) | 82 (47.1) | 25 (14.4) | 0.023 | Control | 216 (62.1) | 132 (37.9) | 0.008 | ||
| Female | Case | 41 (35.3) | 57 (49.1) | 18 (15.5) | Case | 139 (59.9) | 93 (40.1) | |||
| Control | 37 (39.8) | 35 (37.6) | 21 (22.6) | 0.201 | Control | 109 (58.6) | 77 (41.4) | 0.786 | ||
| rs17037564 | AA | AG | GG | A | G | |||||
| Total | Case | 8 (2.0) | 80 (19.9) | 314 (78.1) | Case | 96 (11.9) | 708 (88.1) | |||
| Control | 5 (1.3) | 52 (19.5) | 254 (78.7) | 0.984 | Control | 62 (11.6) | 472 (88.4) | 0.855 | ||
| Male | Case | 4 (1.4) | 55 (19.2) | 227 (79.4) | Case | 63 (11.0) | 509 (89.0) | |||
| Control | 3 (1.7) | 32 (18.4) | 139 (79.9) | 0.942 | Control | 38 (10.9) | 310 (89.1) | 0.964 | ||
| Female | Case | 4 (3.4) | 25 (21.6) | 87 (75.0) | Case | 33 (14.2) | 199 (85.8) | |||
| Control | 2 (2.2) | 20 (21.5) | 71 (76.3) | 0.854 | Control | 24 (12.9) | 162 (87.1) | 0.695 | ||
Abbreviations: SNPs, single-nucleotide-polymorphisms; *P and **P values representing the comparison of genotype frequencies and allelic frequencies, respectively.