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. 2020 Jul 1;13(7):1590–1600.

Figure 4.

Figure 4

CLDN6-mediated Smads signaling pathway regulates the expression of MMP2 and MMP9. (A) RT-PCR and (B) immunoblot expression analyses of MMP2 and MMP9 in MCF-7 cells treated with or without SB431542, MCF-7-shGFP, and MCF-7-shCLDN6 pretreated with SB431542, and densitometric analysis of relative expression levels after normalization to loading control GAPDH or β-actin are presented (*P < 0.05 and **P < 0.01 are significant and highly significant, respectively). Bars represent mean ± SE (n = 3).