. 2020 Jul 1;13(7):1915–1923.

Table 1.

The main clinical features of the 17 FL patients with PNP or BO

Case Num.	References	Age	Gender	Clinical stage	FL Level	Diagnostic Time of PNP	Diagnostic Time of BO	Treatment Plan	Curative effect	Prognosis
1	Moustafa, et al. [6]	68	M	Unknown	I	Simultaneous diagnosis with tumor	Unknown	B^/R^→R^*/Prednisone	Improvement of skin lesion	Died of infectious complications 10 months after diagnosis.
									Tumor shrinking
									The symptoms of infection are still repeated.
2	Lee, et al. [7]	53	M	IVA	Unknown	Simultaneous diagnosis with tumor	Simultaneous diagnosis with PNP	R-CHOP^*	Complete remission of tumor, stomatitis, other skin lesions and BO are persistent existence.	Died of respiratory failure caused by BO 27 months after diagnosis.
3	Borradori, et al. [8]	61	F	Unknown	I	Simultaneous diagnosis with tumor	Unknown	P^→CHOP^/antibiotics/Cyclosporin/0.5% Retinaldehyde/Sucralfate→R^*	The tumor was relieved and there was no progress. Stomatitis and palmar erythema were relieved and the patient was well tolerated by rituximab.	Unknown
4	Aoi, et al. [9]	60	M	Unknown	Unknown	Simultaneous diagnosis with tumor	Unknown	P^→P^/R^→R^ combined with chemotherapy	The condition improved and the skin lesion recovered. The FL was relieved partly.	Unknown
5	Lim, et al. [10]	58	M	Unknown	Unknown	Simultaneous diagnosis with tumor	1 week after PNP diagnosis	Before BO: R-CHOP^*	Atypical pneumonia caused by cytomegalovirus infection one week after treatment.	Died of septic shock one month after diagnosis of BO.
5	Lim, et al. [10]	58	M	Unknown	Unknown	Simultaneous diagnosis with tumor	1 week after PNP diagnosis	After BO: R-CHOP^*		Died of septic shock one month after diagnosis of BO.
6	Lachenal, et al. [11]	52	F	Unknown	Unknown	Simultaneous diagnosis with tumor	Unknown	R-CHOP^*	The skin lesions were improved obviously, the oral erosion was improved, but the tumor reaction was unknown.	Unknown
7	Higo, et al. [12]	77	F	Unknown	Unknown	Simultaneous diagnosis with tumor	Unknown	R-CHOP^→Bendamustine/R^→Prednisone	The skin lesion recovered and the mucosal rash did not improve.	Unknown
8	Morikawa, et al. [13]	65	F	IIIA	Unknown	Simultaneous diagnosis with tumor	5 months after FL diagnosis	Before BO: R-CHOP^→R^→R-CVP^*	The tumor shrank and the symptoms such as conjunctivitis, oral mucosal ulcer and the rash improved.	Unknown
8	Morikawa, et al. [13]	65	F	IIIA	Unknown	Simultaneous diagnosis with tumor	5 months after FL diagnosis	After BO: Palliative and symptomatic treatment		Unknown
9	Jain, et al. [14]	60	M	IVB	I	29 months after FL diagnosis	Unknown	Bendamustine/R^→R^	The tumor was remission completely at the beginning and relapsed after 18 months.	Unknown
10	Hirano, et al. [15]	60	M	Unknown	Unknown	Simultaneous diagnosis with tumor	3 months after FL diagnosis	Before BO: R^*/Prednisone	The blisters disappeared completely and the autoantibodies decreased to the normal level.	Died 7 months after the diagnosis of BO.
								After BO: Plasma exchange	But the BO appeared later.
								→R-CHOP^→Bendamustine/R^
11	Hoque, et al. [16]	49	F	Unknown	Unknown	9 years after FL diagnosis	Unknown	CHOP^→Radiotherapy/F^/Mitoxanone/Prednisone→F→R-CVP^*	The tumor was completely relieved, the rash improved after treatment, but the general condition of the patient was poor.	After the occurrence of PNP, the condition worsened and the patient died after palliative treatment.
12	Martínez, et al. [17]	70	F	IVA	I	4 years after FL diagnosis	Unknown	CHOP^*→Chlorambutyronitrile→P	The tumor was completely relieved, the skin blisters disappeared, but the lesions of oral mucosa persisted.	40 months after the diagnosis of PNP, there was no recurrence of skin and mucosal lesions.
13	Prodanovic, et al. [18]	73	M	IV	I	3 years after FL diagnosis	Unknown	R^/F^/D^/Mitoxantrone/Granisetron→R^	The tumor was relieved, the skin blisters were cured and there was no recurrence during the follow-up period.	Unknown
14	Maruta, et al. [19]	70	M	IVB	Unknown	5 years after FL diagnosis	Unknown	Chlorambutyronitrile/C^/O^→P^/F^/Chlorambutyronitrile→P^/Radiotherapy→Chlorambutyronitrile/P^→D^/Azathioprine→R^/P^*	The tumor was relieved, the skin lesions were improved, but the oral mucosal lesions were relieved very little.	Died of left heart failure and pulmonary edema 9 months after the diagnosis of PNP.
15	Heizmann, et al. [20]	73	F	Unknown	Unknown	Simultaneous diagnosis with tumor	Unknown	P^/C^→R^/P^	The tumor was relieved partly and conjunctival and mucosal erosion recovered completely.	Unknown
16	Barnadas, et al. [21]	77	F	IIB	Unknown	Later than FL diagnosis time, the certain time is unknown	Unknown	Chlorophenylbutyronitrile→P^/Valaciclovir→R^/P^→P^/Cyclosporin	The tumor was relieved partly and the oral ulcer was completely cured.	The patient died 42 months after the FL diagnosis. The cause of death is unknown, but acid-fast bacilli is active.
17	Present case	54	F	IV	I-II	Simultaneous diagnosis with tumor	11 months after FL diagnosis	R-CHOP^* and so on	The FL was relieved and mucositis and vulvar lesions were improved.	Died of respiratory failure caused by BO 11 months after the diagnosis of PNP.

R: Rituximab; C: Cyclophosphamide; O/V: Vincristine; P: Prednisone; D: Dexamethasone; F: Fludarabine.