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. 2020 Aug 8;22:84. doi: 10.1186/s13058-020-01325-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — SRC and HER2 inhibitors increase endocrine sensitivity of HCC1428 cells expressing endogenous ESR1–CCDC170 fusion. a Sensitivity of HCC1428 cells to tamoxifen in combination with selective targeted agents as measured by clonogenic assays. HCC1428 cells were treated with different dosages of 4-OH tamoxifen (μM), or 4-OH tamoxifen plus lapatinib (2 μM), dasatinib (0.05 μM), BEZ235 (8 nM), or AZD8931 (1 uM). Data were normalized against vehicle treatment alone (as 100%). b Sensitivity of HCC1428 cells to fulvestrant in combination with selective targeted agents as measured by clonogenic assays. HCC1428 cells were treated with different dosages of fulvestrant (μM), or fulvestrant plus lapatinib (2 μM), dasatinib (0.05 μM), BEZ235 (8 nM), AZD8931 (1 uM), or lapatinib (2 μM) + dasatinib (0.05 μM). Data were normalized against vehicle treatment alone (as 100%). Tam, 4-OH tamoxifen; Ful, fulvestrant, Lapa, lapatinib; Dasa, dasatinib, BEZ, BEZ235, AZD, ZAD8931. ***P < 0.001 (two-way ANOVA)