Figure 4.

The combination of DEX and RUX cooperatively attenuates disease manifestations in an in vivo model of HLH. (A) Bodyweight over time relative to baseline bodyweight of naïve mice and vehicle- and drug-treated LCMV-infected mice. Statistical significance is relative to the naïve condition. (B) Survival of naïve mice and vehicle- and drug-treated LCMV-infected mice. (C) Plasma ferritin levels in naïve mice and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (D) Hematocrit (HCT) values in naïve mice and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (E) Platelet count in naïve mice and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (F) Spleen weight as percentage of initial bodyweight and representative spleen images from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (G) Number of monocytes in spleens from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (H) Number of neutrophils in spleens from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (I) Representative histologic images and percentage of total area staining positively for Ly6B.2 in livers from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. Statistical significance was assessed using 1-way ANOVA with Tukey’s method for multiple comparisons adjustment (A, C-I). With the exception of panels B and I, all data represent a combined analysis of 2 independent experiments. ****P < .0001; ***P < .001; **P < .01; *P < .05.