Table 3.
The main results of the overall meta-analysis of CACNA1C polymorphisms
| Genetic model | OR | 95% CI | P-value | I2(%) | Ph | Combination method |
|---|---|---|---|---|---|---|
| Rs1006737 | ||||||
| Allele contrast | 1.151 | 1.100–1.204 | 0.000 | 0.0 | 0.867 | Fixed effects model |
| Dominant | 1.169 | 1.107–1.234 | 0.000 | 0.0 | 0.786 | Fixed effects model |
| Recessive | 1.215 | 1.085–1.360 | 0.001 | 0.0 | 0.999 | Fixed effects model |
| Codominance AA vs. GG | 1.296 | 1.151–1.459 | 0.000 | 0.0 | 0.993 | Fixed effects model |
| Codominance GA vs. GG | 0.064 | 0.024–0.169 | 0.000 | 99.0 | 0.000 | Random effects model |
| Complete overdominance | 0.897 | 0.849–0.948 | 0.000 | 26.1 | 0.173 | Fixed effects model |
| Rs2007044 | ||||||
| Allele contrast | 1.080 | 1.023–1.139 | 0.006 | 0.0 | 0.785 | Fixed effects model |
| Rs4765905 | ||||||
| Allele contrast | 1.225 | 1.100–1.364 | 0.000 | 0.0 | 0.719 | Fixed effects model |
Notes: I2 represents the variation in OR attributable to heterogeneity. Ph represents the P-value of the Q-test for heterogeneity
Abbreviations:CI confidence interval; OR odds ratio