Table 2.

Descriptive variables and impact of each factor on dementia incidence across 8 years, based on univariable models, with death as a competing event

Risk factors	Without dementia	Incident dementia	χ2 test	Death (competing event)		Dementia
	N = 989	N = 111	P value	SHR (95% CI)	P value	SHR (95% CI)	P value
Non-modifiable
Age (class 1935–37)	522 (52.7)	69 (62.2)	0.060	1.21 (0.82–1.78)	0.332	1.20 (0.82–1.78)	0.347
Sex (female)	534 (54.0)	55 (49.5)	0.373	0.76 (0.53–1.11)	0.156	0.82 (0.56–1.19)	0.287
APOE ε4	166 (16.8)	34 (30.6)	< 0.001	0.92 (0.47–12.16)	0.742	2.00 (1.34–3.01)	0.001
Modifiable
Low education	548 (55.4)	69 (62.2)	0.174	1.15 (0.79–1.68)	0.459	1.38 (0.94–2.03)	0.103
Obesity	259 (27.3)	29 (27.9)	0.908	0.68 (0.42–1.09)	0.107	1.08 (0.70–1.66)	0.716
Hypertension	685 (69.4)	81 (73.6)	0.359	1.08 (0.72–1.63)	0.697	1.27 (0.83–1.94)	0.270
Diabetes	198 (20.2)	31 (28.2)	0.053	1.30 (0.84–12.96)	0.200	1.55 (1.02–2.36)	0.042
Depression	51 (5.2)	5 (4.5)	0.767	2.11 (1.07–4.16)	0.032	0.99 (0.40–2.45)	0.984
Smoking	86 (8.7)	11 (9.9)	0.669	2.04 (1.24–3.37)	0.005	1.12 (0.60–2.09)	0.715
Physical inactivity	462 (46.8)	60 (54.1)	0.145	1.27 (0.88–1.84)	0.203	1.42 (0.98–2.06)	0.064
Hearing loss	123 (12.5)	16 (14.5)	0.539	1.07 (0.62–1.83)	0.803	1.20 (0.71–2.02)	0.493
Loneliness	117 (11.9)	10 (9.1)	0.388	1.31 (0.77–2.21)	0.316	0.82 (0.42–1.59)	0.562
Heart disease	255 (25.8)	42 (37.8)	0.007	1.29 (0.87–1.91)	0.206	1.61 (1.09–2.37)	0.016
Stroke	64 (6.5)	20 (18.2)	< 0.001	2.05 (1.18–3.55)	0.011	2.69 (1.67–4.35)	< 0.001
Head injury	77 (7.8)	7 (6.3)	0.576	1.12 (0.55–2.24)	0.757	0.84 (0.39–1.80)	0.649
Delirium	5 (0.5)	7 (6.4)	< 0.001	1.52 (0.37–6.28)	0.562	8.52 (3.62–20.05)	< 0.001

Values represent counts (percentage)

SHR sub-hazard ratio