Table 3.
Independent influence of each risk factor on dementia incidence across 8 years, based on competing risk multivariable model
| Risk factors | Death (competing event) | Dementia | |||
|---|---|---|---|---|---|
| SHR (95% CI) | P value | SHR (95% CI) | P value | % PAF (95% CI) | |
| APOE ε4 | 0.93 (0.57–1.51) | 0.761 | 1.89 (1.22–2.92) | 0.005 | |
| Low education | 1.18 (0.80–1.73) | 0.803 | 1.42 (0.95–2.11) | 0.087 | 18.5 (1.3–23.4) |
| Diabetes | 1.24 (0.80–1.91) | 0.043 | 1.56 (1.00–2.39) | 0.043 | 9.9 (1.9–17.3) |
| Physical inactivity | 1.22 (0.84–1.78) | 0.297 | 1.33 (0.90–1.96) | 0.152 | 13.3 (3.9–27.7) |
| Heart disease | 1.26 (0.85–1.86) | 0.849 | 1.56 (1.03–2.36) | 0.037 | 13.6 (2.8–23.2) |
| Stroke | 2.01 (1.16–3.47) | 0.012 | 2.31 (1.35–3.95) | 0.002 | 10 (5.8–14.0) |
| Delirium | 1.50 (0.34–6.51) | 0.590 | 8.70 (3.26–23.24) | < 0.001 | 5.7 (5.0–6.5) |
SHR sub-hazard ratio, PAF population attributable fraction