Figure 1 |. The structure of teixobactin and the predicted biosynthetic gene cluster.

a, The two NRPS genes, the catalytic domains they encode, and the amino acids incorporated by the respective modules. Domains: A, adenylation; C, condensation; MT, methylation (of phenylalanine); T, thiolation (carrier); and TE, thioesterase (Ile-Thr ring closure). NmPhe, N-methylated phenylalanine. b, Schematic structure of teixobactin. The N-methylation of the first phenylalanine is catalysed by the methyltransferase domain in module 1. The ring closure between the last isoleucine and threonine is catalysed by the thioesterase domains during molecule off-loading, resulting in teixobactin. c, Teixobactin structure.