. Author manuscript; available in PMC: 2020 Aug 8.

Published in final edited form as: Nature. 2015 Jan 7;517(7535):455–459. doi: 10.1038/nature14098

Table 1 |.

Activity of teixobactin against pathogenic microorganisms

Organism and genotype	Teixobactin MIC(μg ml⁻¹)
S. aureus (MSSA)	0.25
S. aureus + 10% serum	0.25
S. aureus (MRSA)	0.25
Enterococcus faecalis (VRE)	0.5
Enterococcus faecium (VRE)	0.5
Streptococcus pneumoniae (penicillin^R)	≤ 0.03
Streptococcus pyogenes	0.06
Streptococcus agalactiae	0.12
Viridans group streptococci	0.12
B. anthracis	≤ 0.06
Clostridium difficile	0.005
Propionibacterium acnes	0.08
M. tuberculosis H37Rv	0.125
Haemophilus influenzae	4
Moraxella catarrhalis	2
Escherichia coli	25
Escherichia coli (asmB1)	2.5
Pseudomonas aeruginosa	>32
Klebsiella pneumoniae	>32

The MIC was determined by broth microdilution. MSSA, methicillin-sensitive S. aureus; VRE, vancomycin-resistant enterococci.