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. 2020 Aug 7;11:3948. doi: 10.1038/s41467-020-17788-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a In Dataset 1, cLBP patients (pre- and post-maneuver) had significantly lower fraction rate and dwell time in State 1 and higher fraction rate and dwell time in State 2. This finding was validated in Dataset 2. Data are presented as mean values ± SEM. Each circle represents the data for an individual. N = 90 and 74 for cLBP patients and HCs in Dataset 1, respectively, and N = 30 and 30 for cLBP patients and HCs in Dataset 2, respectively. b The fraction rate and dwell time of cLBP patients in State 2 were positively correlated with pain severity/intensity in the past 7 days. Note that pain severity and intensity are two different measures but are typically strongly correlated. c cLBP patients and HCs had similar patterns of connectivity in the two states, but they differed in the strength of connections. Asterisks represent significant difference at two-sided p_FDR < 0.05 for t-test. SMN sensorimotor network, DMN default mode network, SCN subcortical network, FPN frontoparietal network, VSN visual network, ADN auditory network. Source data are provided as a Source Data file.