Fig. 5. Group differences of thalamus-whole-brain dFNC in two dynamic states.
a Two seeds, including the ventral lateral/posterolateral (VL/VPL) nucleus and dorsal/ventral medial (DM/VM) nucleus were identified by GICA and used in seed-based correlation analysis. b In State 2, cLBP patients had higher dFNC between the VL/VPL and postcentral gyrus (PCoG)/paracentral lobule (ParaCL) and c lower dFNC between the DM/VM and insula (INS). d In State 1, patients had weaker dFNC between the VL/VPL and visual cortex but stronger dFNC between the VL/VPL and PoCG and typical regions (i.e., medial prefrontal cortex [mPFC], posterior cingulate cortex [PCC], and angular gyrus [AG]) of the DMN. Data are presented as mean values ± SEM (N = 90 and 74 for cLBP patients and HCs, respectively). We performed two sample t-test for panels b and c, and paired sample t-test for panel d, and reported two-sided p values. Statistical maps were thresholded at p < 0.005 at voxel level and pFDR < 0.05 at the cluster level. Comparisons of bars in panel D were corrected for multiple comparisons using FDR. Asterisks represent significant differences at two-sided pFDR < 0.05. Source data are provided as a Source Data file.