Table 1.
Familial and sporadic ALS SOD1 mutation carrier samples.
| Familial or sporadic | Family or sporadic ID | Number of samples | Number of pairsa | SOD1 mutation |
|---|---|---|---|---|
| Sporadic | SALS | 3 | – | p.I114T |
| Familial | 3 | 6 | 15 | p.E101G |
| Familial | 12 | 15 | 105 | p.I114T |
| Familial | 18 | 32b | 496 | p.V149G |
| Familial | 35 | 1 | 0 | p.V149G |
| Familial | 43 | 2 | 1 | p.I114T |
| Familial | 76 | 1 | 0 | p.I114T |
| Familial | 95 | 2 | 1 | p.I114T |
| Familial | 98 | 1 | 0 | p.I114T |
| Familial | 106 | 1 | 0 | p.I114T |
| Familial | 123 | 1 | 0 | p.I114T |
| Familial | 124 | 2 | 1 | p.I114T |
| Familial | 130 | 1 | 0 | p.I114T |
| Familial | 131 | 1 | 0 | p.I114T |
| Familial | 132 | 3 | 3 | p.E101G |
| Familial | 197 | 2 | 1 | p.I114T |
| Familial | 213 | 1 | 0 | p.I114T |
| Familial | 259 | 1 | 0 | p.I114T |
| Familial | 267 | 1 | 0 | p.I114T |
| Familial | 270 | 1 | 0 | p.I114T |
| Familial | 274 | 1 | 0 | p.I114T |
| Familial | 286 | 1 | 0 | p.I114T |
| Familial | 334 | 2 | 1 | p.I114T |
| Familial | 374 | 2 | 1 | p.I114T |
| Familial | mq10 | 1 | 0 | p.I114T |
| Familial | mq36 | 1 | 0 | p.I114T |
| Total | – | 86 | 625 | – |
aThe number of pairwise comparisons between samples was calculated for familial samples only and was simply the number of unordered 2-sample combinations, i.e. n-choose-2, where n was the number of samples.
bWGS data from five additional samples did not pass WGS-processing quality thresholds and were not used in subsequent analyses.