Table 3.

Summary of Australian ALS clinical information for each of the five SOD1 clusters.

Cluster	SOD1 mutation	No. of mutation carriers	% Male	% Spinal [n]	Mean age (years) at onset ± SD (range) [n]	Mean age (years) at death ± SD (range) [n]	Mean disease duration (months) ± SD (range) [n]
C1	p.I114T	41	41%	94% [16]	57.1 ± 14.5 (29.5–76.0) [16]	61.5 ± 12.6 (35.1–78.2) [18]	64.1 ± 45.7 (28.5–177.1) [11]
C4	p.I114T	3	33%	100% [3]	40.8 ± 12.5 (30.2–54.5) [3]	NA	NA
C2	p.V149G	33	60%	75% [16]	43.0 ± 8.7 (25.1–57.6) [17]	44.8 ± 7.8 (25.8–53.8) [21]	29.5 ± 34.3 (7.8–145.0) [16]
C3	p.E101G	6	50%	100% [4]	48.6 ± 9.9 (36.2–60.2) [4]	64.2 ± 15.2 (45.9–83.0) [4]	119.8 ± 59.1 (62.8–180.9) [3]
C5	p.E101G	3	67%	50% [2]	42.6 [1]	51.7 ± 11.7 (43.6–65.1) [3]	46.0 [1]

Number of cases with available clinical data is indicated by square brackets.

SD standard deviation.