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. 2020 Aug 7;10:13378. doi: 10.1038/s41598-020-70125-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predictors: onset (b), sex (c); age (d); symptom duration in month (e); baseline weight in kg (f), baseline ALSFRS score (g); and estimated ALSFRS loss rate (h) distribution with regards to UMAP projection (a). Each point represents an individual patient. Age ranges between 18 and 81 years old (d), symptom duration ranges between 0.5 and 87 months (e), baseline weight ranges between 30 and 130 kg (f), ALSFRS score ranges between 0 and 40 (g) and estimated baseline ALSFRS slope ranges between 0.00 and − 1.50 ALSFRS points per month (h). Axes are dimensionless and come from UMAP dimension reduction.