Table 4.

Predictor distribution per survival area.

Feature	PRO-ACT	Exonhit	Trophos	Real world	Overall
Initial sample size (n)	10,723	400	512	1,377	13,012
Gender	$0\%$	$0\%$	$0\%$	$0\%$	$0\%$
Onset	$12\%$	$0\%$	$0\%$	$2\%$	$10\%$
Age	$28\%$	$0\%$	$0\%$	$0\%$	$23\%$
Symptom duration	$36\%$	$0\%$	$0\%$	$0\%$	$30\%$
Baseline weight	$39\%$	$3\%$	$1\%$	$3\%$	$33\%$
Baseline height	$38\%$	$0\%$	$100\%$	$3\%$	$35\%$
Baseline ALSFRS	$36\%$	$2\%$	$0\%$	$0\%$	$30\%$
Baseline ALSFRS upper limb sub-score	$39\%$	$0\%$	$0\%$	$0\%$	$36\%$
Baseline ALSFRS lower limb sub-score	$39\%$	$0\%$	$100\%$	$0\%$	$36\%$
Baseline ALSFRS bulbar sub-score	$39\%$	$0\%$	$100\%$	$0\%$	$36\%$
Baseline ALSFRS respiratory sub-score	$39\%$	$0\%$	$100\%$	$0\%$	$36\%$
Baseline ALSFRS trunk sub-score	$39\%$	$0\%$	$100\%$	$0\%$	$36\%$
Baseline pulse	$32\%$	$1\%$	$100\%$	$100\%$	$41\%$
Baseline diastolic blood pressure	$32\%$	$1\%$	$0\%$	$100\%$	$37\%$
Baseline systolic blood pressure	$32\%$	$1\%$	$0\%$	$100\%$	$37\%$
Baseline vital capacity (L)	$23\%$	$1\%$	$0\%$	$100\%$	$29\%$
Baseline vital capacity ($\%$)	$10\%$	$1\%$	$0\%$	$100\%$	$19\%$
Survival (month)	$68\%$	$55\%$	$80\%$	$66\%$	$68\%$
1-year survival	$46\%$	$15\%$	$16\%$	$59\%$	$45\%$
1-year ALSFRS	$66\%$	$42\%$	$30\%$	$75\%$	$65\%$
Overall missing ratio	$35\%$	$6\%$	$41\%$	$35\%$	$34\%$
Overall predictor missing ratio	$30\%$	$1\%$	$41\%$	$30\%$	$30\%$
Overall outcome missing ratio	$60\%$	$37\%$	$42\%$	$67\%$	$59\%$
Final sample size for 1-year survival (n)	3,971	172	646	431	5,220