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Active irinotecan derivative SN-38 coupled to a MAb with a cleavable linker at the heterocycle’s 20 ring oxygen position designed to produce the free active drug upon bond cleavage. The remaining linker consists of a solubilizing 7-PEG unit to counter the free drugs inherent hydrophobicity leading to a maleimide used for coupling to MAb cysteinyl- thiol groups.
