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. 2020 Aug 8;20:121. doi: 10.1186/s12902-020-00575-8

Table 2.

Distribution of genotype and allele among T1DM patients and controls

Study author T1DM cases Healthy control P-HWE MAF
FF Ff ff F f FF Ff Ff F f
FokI (rs2228570)
    Ban et al. [33] 50 52 6 152 64 82 138 30 302 198 0.01 0.396
    Fassbender et al. [34] 35 30 10 100 50 19 30 8 68 46 0.48 0.403
    Gyorffy et al. [35] 32 56 19 120 94 34 47 22 115 91 0.44 0.441
    Turpeinen (Turku) et al. [36] 50 150 74 250 298 102 414 292 618 998 0.01 0.617
    Turpeinen (Tampere) et al. [36] 7 28 20 42 68 61 226 170 348 566 0.29 0.619
    Turpeinen (Oulu) et al. [36] 37 114 98 188 310 93 360 342 546 1044 0.9 0.656
    Audi (barcellona) et al. [37] 69 68 18 206 104 105 142 28 352 198 0.04 0.36
    Audi (navarra) et al. [37] 35 45 6 115 57 41 53 22 135 97 0.51 0.418
    San Pedro et al. [38] 31 35 5 97 45 41 39 8 121 55 0.76 0.312
    Zemunik et al. [39] 42 63 29 147 121 73 136 23 282 182 < 0.001 0.392
    Capoluongo et al. [40] 89 112 45 290 202 91 127 28 309 183 0.09 0.371
    Lemos et al. [41] 81 101 25 263 151 97 114 38 308 190 0.63 0.381
    Israni et al. [42] 142 79 15 363 109 116 76 5 308 86 0.06 0.218
    Mory et al. [43] 80 81 16 241 113 91 67 24 249 115 0.04 0.315
    Panierakis et al. [15] 50 43 7 143 57 64 31 1 159 33 0.18 0.171
    Yavuz et al. [44] 61 46 10 168 66 60 63 11 183 85 0.32 0.317
    Yokota et al. [45] 50 46 12 146 70 59 20 141 138 302 < 0.001 0.686
    Bonakdaran et al. [46] 38 25 6 101 37 18 20 7 56 34 0.71 0.377
    Sahin et al. [47] 54 31 0 139 31 43 28 9 114 46 0.19 0.287
    Mohammadnejad et al. [48] 49 33 5 131 43 55 40 5 150 50 0.5 0.25
    Vedralova et al. [49] 38 60 18 136 96 25 76 12 126 100 < 0.001 0.442
    Greer et al. [50] 21 21 8 63 37 28 22 5 78 32 0.82 0.29
    Hamed et al. [51] 24 92 16 140 124 8 28 4 44 36 0.008 0.45
    Abd-Allah et al. [52] 58 50 12 166 74 78 38 4 194 46 0.8 0.191
    Kafoury et al. [53] 23 21 16 67 53 41 12 7 94 26 0.001 0.216
    Nasreen et al. [54] 32 12 0 76 12 25 19 0 69 19 0.06 0.215
    Mukhtar et al. [55] 84 13 5 181 23 100 0 0 200 0 < 0.001 0
    Ali et al. [56] 64 33 3 161 39 79 21 2 179 25 0.66 0.122
    Rasoul et al. [57] 178 30 45 386 120 146 67 1 359 69 0.02 0.161
Study author T1DM cases Healthy control P-HWE MAF
TT Tt tt T t TT Tt tt T t
TaqI (rs731236)
    Chang et al. [58] 142 15 0 299 15 233 14 1 480 16 0.13 0.032
    Fassbender et al. [34] 34 31 10 99 51 19 20 18 58 56 0.02 0.491
    Gyorffy et al. [35] 46 34 27 126 88 42 27 34 111 95 < 0.001 0.461
    Skrabic et al. [59] 54 55 25 163 105 48 72 12 168 96 0.04 0.363
    Bianco et al. [60] 10 18 3 38 24 11 20 5 42 30 0.39 0.416
    San Pedro et al. [38] 24 36 11 84 58 31 43 14 105 71 0.88 0.403
    Garcia et al. [61] 115 79 22 309 123 121 69 13 311 95 0.46 0.233
    Lemos et al. [41] 70 94 41 234 176 91 95 46 277 187 0.02 0.403
    Israni et al. [42] 91 112 33 294 178 80 98 19 258 136 0.15 0.345
    Panierakis et al. [15] 34 59 7 127 73 10 64 22 84 108 < 0.001 0.562
    Yavuz et al. [44] 37 58 22 132 102 41 66 27 148 120 0.96 0.447
    Bonakdaran et al. [46] 34 28 7 96 42 20 17 8 57 33 0.21 0.366
    Mohammadnejad et al. [48] 32 52 3 116 58 59 41 0 159 41 < 0.001 0.205
    Greer et al. [50] 18 26 6 62 38 26 24 5 76 34 0.87 0.309
    Abd-Allah et al. [52] 42 66 12 150 90 33 69 18 135 105 0.06 0.437
    Cheon et al. [62] 66 15 0 147 15 105 8 0 218 8 0.69 0.035
    Khalid et al. [63] 63 22 15 148 52 19 16 15 54 46 0.01 0.46
    Iyer et al. [64] 19 14 17 52 48 16 16 18 48 52 0.01 0.52
    Rasoul et al. [57] 96 96 61 288 218 156 36 22 348 80 < 0.001 0.186
    Ahmed et al. [65] 0 42 8 42 58 0 40 10 40 60 < 0.001 0.6
Study author T1DM cases Healthy control P-HWE MAF
BB Bb bb B b BB Bb bb B b
BsmI (rs1544410)
    Hauache et al. [66] 13 39 26 65 91 12 43 39 67 121 0.97 0.643
    Chang et al. [58] 4 16 137 24 290 1 16 231 18 478 0.22 0.963
    Fassbender et al. [34] 14 35 26 63 87 18 25 14 61 53 0.37 0.464
    Gyorffy et al. [35] 19 46 42 84 130 16 53 34 85 121 0.53 0.587
    Motohashi et al. [67] 12 64 127 88 318 1 49 172 51 393 0.2 0.885
    Skrabic et al. [59] 24 58 52 106 162 17 74 41 108 156 0.06 0.59
    Turpeinen (Turku) et al. [36] 97 97 26 291 149 354 388 102 1096 592 0.78 0.35
    Turpeinen (Tampere) et al. [36] 29 22 7 80 36 533 488 154 1554 796 0.01 0.338
    Turpeinen (Oulu) et al. [36] 90 103 33 283 169 403 305 110 1111 525 < 0.001 0.32
    Audi (barcellona) et al. [37] 21 73 59 115 191 46 147 81 239 309 0.13 0.563
    Audi (navarra) et al. [37] 20 43 26 83 95 19 53 44 91 141 0.65 0.607
    Bianco et al. [60] 13 14 4 40 22 14 17 5 45 27 0.96 0.375
    San Pedro et al. [38] 15 40 16 70 72 17 44 27 78 98 0.9 0.556
    Capoluongo et al. [40] 62 125 59 249 243 61 122 63 244 248 0.89 0.504
    Garcia et al. [61] 21 110 77 152 264 14 74 115 102 304 0.65 0.748
    Lemos et al. [41] 43 96 68 182 232 56 107 85 219 277 0.04 0.558
    Shimada et al. [68] 32 165 577 229 1319 7 121 471 135 1063 0.8 0.887
    Israni et al. [42] 79 120 37 278 194 56 94 47 206 188 0.53 0.477
    Mory et al. [43] 60 57 60 177 177 38 74 70 150 214 0.62 0.587
    Panierakis et al. [15] 23 57 20 103 97 38 43 15 119 73 0.62 0.38
    Yavuz et al. [44] 20 57 40 97 137 14 59 61 87 181 0.96 0.675
    Tawfeek et al. [69] 3 18 9 24 36 1 8 5 10 18 0.36 0.642
    Bonakdaran et al. [46] 14 26 29 54 84 16 11 18 43 47 < 0.001 0.522
    Vedralova et al. [49] 43 47 14 133 75 30 33 20 93 73 0.07 0.439
    Mohammadnejad et al. [48] 11 36 40 58 116 9 45 46 63 137 0.66 0.685
    Moubarak et al. [70] 7 25 23 39 71 14 26 10 54 46 0.74 0.46
    Abd-Allah et al. [52] 27 68 25 122 118 48 52 20 148 92 0.36 0.383
    Kafoury et al. [53] 8 13 39 29 91 4 11 41 19 93 0.02 0.83
    Cheon et al. [62] 0 13 68 13 149 1 4 108 6 220 < 0.001 0.973
    Khalid et al. [63] 51 32 17 134 66 19 21 10 59 41 0.35 0.41
    Iyer et al. [64] 8 12 30 28 72 26 12 12 64 36 < 0.001 0.36
    Ali et al. [56] 30 45 25 105 95 62 28 12 152 52 0.005 0.254
    Rasoul et al. [57] 141 83 29 365 141 120 66 28 306 122 < 0.001 0.285
    Ahmed et al. [65] 8 35 7 51 49 32 18 0 82 18 < 0.001 0.19
Study author T1DM cases Healthy control P-HWE MAF
AA Aa aa A a AA Aa aa A a
ApaI (rs7975232)
    Chang et al. [58] 16 76 65 108 206 13 105 130 131 365 0.16 0.735
    Gyorffy et al. [35] 23 27 57 73 141 33 45 25 111 95 0.21 0.461
    Skrabic et al. [59] 66 52 16 184 84 51 66 15 168 96 0.35 0.363
    Turpeinen (Turku) et al. [36] 35 106 57 176 220 152 441 204 745 849 0.001 0.532
    Turpeinen (Tampere) et al. [36] 13 23 20 49 63 69 229 152 367 533 0.25 0.592
    Turpeinen (Oulu) et al. [36] 43 115 81 201 277 165 389 289 719 967 0.09 0.573
    Bianco et al. [60] 18 11 2 47 15 11 20 5 42 30 0.39 0.416
    San Pedro et al. [38] 15 37 19 67 75 28 43 17 99 77 0.94 0.437
    Garcia et al. [61] 54 115 44 223 203 43 125 35 211 195 < 0.001 0.48
    Lemos et al. [41] 55 100 50 210 200 68 101 63 237 227 0.04 0.489
    Israni et al. [42] 85 133 18 303 169 60 110 27 230 164 0.03 0.416
    Panierakis et al. [15] 37 57 6 131 69 23 58 15 104 88 0.03 0.458
    Yavuz et al. [44] 36 58 23 130 104 35 70 31 140 132 0.72 0.485
    Bonakdaran et al. [46] 13 52 4 78 60 18 26 1 62 28 0.01 0.311
    Mohammadnejad et al. [48] 27 48 12 102 72 27 57 16 111 89 0.12 0.445
    Greer et al. [50] 15 24 11 54 46 12 32 11 56 54 0.22 0.49
    Abd-Allah et al. [52] 44 65 11 153 87 36 68 16 140 100 0.06 0.416
    Cheon et al. [62] 5 32 44 42 120 9 34 70 52 174 0.1 0.769
    Khalid et al. [63] 49 44 7 142 58 26 21 3 73 27 0.64 0.27
    Nasreen et al. [54] 14 25 5 53 35 15 25 4 55 33 0.15 0.375
    Iyer et al. [64] 17 16 17 50 50 18 16 16 52 48 0.01 0.48
    Mukhtar et al. [55] 43 26 33 112 92 86 0 14 172 28 < 0.001 0.14
    Rasoul et al. [57] 192 31 29 415 89 162 37 15 361 67 < 0.001 0.156
    Ahmed et al. [65] 24 22 4 70 30 37 13 0 87 13 < 0.001 0.15

P-HWE P value for Hardy–Weinberg equilibrium, MAF minor allele frequency of control group