Table 3.
Main results of pooled ORs in meta-analysis of Vitamin D Receptor gene polymorphisms
| Group | Genetic Model | Case/Control | Test of Association | Test of Heterogenicity | Test of publication bias | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| (Begg’s test) | (Egger’s test) | |||||||||
| OR | 95%CI (P value) | I2 (%) | P | Z | P | T | P | |||
| FokI (rs2228570) | ||||||||||
| Overall | Dominant model | 3723 / 5578 | 0.92 | 0.79–1.08 (0.31) | < 0.001 | < 0.001 | 0.28 | 0.78 | 0.79 | 0.43 |
| Recessive model | 3723 / 5578 | 0.98 | 0.71–1.35 (0.91) | < 0.001 | < 0.001 | 1.43 | 0.15 | 1.28 | 0.21 | |
| Allelic model | 3723 / 5578 | 0.96 | 0.81–1.14 (0.65) | < 0.001 | < 0.001 | 0.71 | 0.47 | 0.87 | 0.39 | |
| ff vs. FF | 3723 / 5578 | 0.96 | 0.69–1.35 (0.83) | < 0.001 | < 0.001 | 1.70 | 0.09 | 1.78 | 0.08 | |
| Ff vs. FF | 3723 / 5578 | 0.94 | 0.79–1.12 (0.49) | < 0.001 | < 0.001 | 1.19 | 0.23 | 1.23 | 0.22 | |
| European | Dominant model | 3723 / 5578 | 0.86 | 0.74–1.00 (0.05) | 0.268 | 0.268 | −0.15 | 0.88 | 0.33 | 0.74 |
| Recessive model | 2077 / 3849 | 1.00 | 0.77–1.30 (0.98) | 0.011 | 0.011 | 0.60 | 0.54 | 1.15 | 0.27 | |
| Allelic model | 2077 / 3849 | 0.93 | 0.82–1.06 (0.28) | 0.015 | 0.015 | - 0.05 | 0.96 | 0.69 | 0.50 | |
| ff vs. FF | 2077 / 3849 | 0.90 | 0.67–1.20 (0.46) | 0.046 | 0.046 | 0.27 | 0.78 | 1.01 | 0.33 | |
| Ff vs. FF | 2077 / 3849 | 0.86 | 0.75–0.99 (0.04) | 0.435 | 0.435 | 0.74 | 0.45 | 0.59 | 0.56 | |
| Asian | Dominant model | 2077 / 3849 | 0.76 | 0.55–1.05 (0.09) | 0.015 | 0.015 | - 0.74 | 0.45 | −0.31 | 0.76 |
| Recessive model | 1107 / 1272 | 0.93 | 0.23–3.68 (0.91) | < 0.001 | < 0.001 | 1.65 | 0.09 | 3.26 | 0.02 | |
| Allelic model | 1107 / 1272 | 0.78 | 0.46–1.33 (0.36) | < 0.001 | < 0.001 | − 0.25 | 0.80 | 0.04 | 0.97 | |
| ff vs. FF | 1107 / 1272 | 0.87 | 0.25–3.01 (0.82) | < 0.001 | < 0.001 | 1.95 | 0.05 | 3.01 | 0.03 | |
| Ff vs. FF | 1107 / 1272 | 0.84 | 0.53–1.34 (0.47) | < 0.001 | < 0.001 | 0.49 | 0.62 | 0.50 | 0.63 | |
| African | Dominant model | 1107 / 1272 | 2.06 | 1.20–3.53 (0.008) | 0.225 | 0.225 | - 0.52 | 0.60 | −0.19 | 0.88 |
| Recessive model | 312 /220 | 2.14 | 1.03–4.43 (0.04) | 0.382 | 0.382 | - 0.52 | 0.60 | −0.60 | 0.65 | |
| Allelic model | 312 /220 | 1.77 | 1.06–2.97 (0.02) | 0.057 | 0.057 | 0.52 | 0.60 | 0.23 | 0.85 | |
| ff vs. FF | 312 /220 | 3.11 | 1.44–6.69 (0.004) | 0.493 | 0.493 | - 1.57 | 0.11 | −1.65 | 0.34 | |
| Ff vs. FF | 312 /220 | 1.81 | 1.13–2.91 (0.01) | 0.337 | 0.337 | - 0.52 | 0.60 | 0.03 | 0.98 | |
| TaqI (rs731236) | ||||||||||
| Overall | Dominant model | 1873 / 1895 | 1.06 | 0.78 – 1.45 (0.70) | 78.3 | < 0.001 | − 0.45 | 0.65 | −1.61 | 0.12 |
| Recessive model | 1873 / 1895 | 0.91 | 0.66 – 1.26(0.58) | 59.1 | 0.001 | −1.93 | 0.05 | −1.93 | 0.07 | |
| Allelic model | 1873/ 1895 | 1.02 | 0.81 – 1.29 (0.86) | 81.9 | < 0.001 | −0.24 | 0.80 | − 0.96 | 0.34 | |
| tt vs. TT | 1873 / 1895 | 0.90 | 0.58 – 1.39 (0.62) | 72.9 | < 0.001 | −2.14 | 0.03 | −2.65 | 0.01 | |
| Tt vs.TT | 1873 / 18995 | 1.12 | 0.84– 1.49 (0.45) | 70.7 | < 0.001 | −0.39 | 0.69 | −1.04 | 0.31 | |
| European | Dominant model | 840 / 878 | 0.82 | 0.59–1.13 (0.23) | 49.1 | 0.056 | −1.48 | 0.13 | −1.88 | 0.11 |
| Recessive model | 840 / 878 | 0.78 | 0.50–1.21 (0.26) | 55.1 | 0.029 | −1.24 | 0.21 | −0.95 | 0.38 | |
| Allelic model | 840 / 878 | 0.92 | 0.76–1.11 (0.36) | 9.6 | 0.356 | −1.73 | 0.08 | −1.27 | 0.25 | |
| tt vs. TT | 840 / 878 | 0.75 | 0.44–1.27 (0.28) | 61.1 | 0.012 | −1.73 | 0.08 | −1.68 | 0.14 | |
| Tt vs.TT | 840 / 878 | 0.87 | 0.64–1.20 (0.40) | 39.8 | 0.114 | − 0.99 | 0.32 | −1.10 | 0.31 | |
| Asian | Dominant model | 1033 / 1017 | 1.40 | 0.75 – 2.58 (0.28) | 85.7 | < 0.001 | 0 | 1 | −1.08 | 0.31 |
| Recessive model | 1033 / 1017 | 1.05 | 0.51 – 2.16 (0.88) | 74.5 | 0.008 | −2.44 | 0.01 | −3.55 | 0.02 | |
| Allelic model | 1033 / 1017 | 1.27 | 0.75 – 2.14 (0.36) | 88.7 | < 0.001 | 0 | 1 | −0.75 | 0.45 | |
| tt vs. TT | 1033 / 1017 | 1.03 | 0.37 – 2.85 (0.95) | 85.4 | < 0.001 | −1.69 | 0.09 | −3.10 | 0.03 | |
| Tt vs.TT | 1033 / 1017 | 1.46 | 0.83 – 2.58 (0.19) | 80.1 | < 0.001 | − 0.83 | 0.40 | − 0.77 | 0.46 | |
| BsmI (rs1544410) | ||||||||||
| Overall | Dominant model | 4826 / 7159 | 1.02 | 0.80– 1.30 (0.88) | 76.3 | < 0.001 | −0.25 | 0.80 | 0.48 | 0.63 |
| Recessive model | 4826 / 7159 | 0.94 | 0.80 – 1.10 (0.45) | 52.9 | < 0.001 | 0.13 | 0.89 | 0.20 | 0.84 | |
| Allelic model | 4826 / 7159 | 0.99 | 0.86 – 1.15 (0.92) | 77.6 | < 0.001 | 0.21 | 0.83 | 0.16 | 0.87 | |
| bb vs. BB | 4826 / 7159 | 0.96 | 0.75– 1.23 (0.74) | 59.8 | < 0.001 | −0.59 | −0.55 | −0.69 | 0.49 | |
| Bb vs. BB | 4826 / 7159 | 1.07 | 0.88 – 1.29 (0.52) | 53.9 | < 0.001 | −0.19 | 0.84 | −0.58 | 0.56 | |
| European | Dominant model | 1938 / 4450 | 0.94 | 0.71–1.24 (0.66) | 71.0 | < 0.001 | −0.25 | 0.80 | 0.89 | 0.39 |
| Recessive model | 1938 / 4450 | 1.00 | 0.85–1.19 (0.95) | 20.7 | 0.223 | −0.25 | 0.80 | −0.63 | 0.54 | |
| Allelic model | 1938 / 4450 | 1.00 | 0.89–1.13 (0.93) | 41.7 | 0.046 | −0.35 | 0.72 | −0.75 | 0.46 | |
| bb vs. BB | 1938 / 4450 | 0.99 | 0.80–1.23 (0.92) | 16.1 | 0.273 | 0.05 | 0.96 | −0.57 | 0.57 | |
| Bb vs. BB | 1938 / 4450 | 1.05 | 0.89–1.25 (0.56) | 15.0 | 0.286 | −0.45 | 0.65 | −0.99 | 0.34 | |
| Asian | Dominant model | 2195 /2004 | 1.05 | 0.61 – 1.79 (0.87) | 77.8 | < 0.001 | − 0.12 | 0.90 | −0.38 | 0.71 |
| Recessive model | 2195 /2004 | 1.02 | 0.73 – 1.40 (0.92) | 65.7 | < 0.001 | −0.38 | 0.70 | 0.18 | 0.86 | |
| Allelic model | 2195 /2004 | 1.00 | 0.72 – 1.38 (0.97) | 85 | < 0.001 | 0.38 | 0.70 | 0.24 | 0.81 | |
| bb vs. BB | 2195 /2004 | 1.07 | 0.55 – 2.09 (0.84) | 76.8 | < 0.001 | −0.12 | 0.90 | −0.42 | 0.68 | |
| Bb vs. BB | 2195 /2004 | 1.07 | 0.67 – 1.71(0.77) | 63.5 | < 0.001 | 0.12 | 0.90 | −0.49 | 0.63 | |
| American | Dominant model | 463 / 479 | 0.57 | 0.39–0.84 (0.004) | 0.0 | 0.755 | 1.57 | 0.11 | 14.1 | 0.04 |
| Recessive model | 463 / 479 | 0.62 | 0.41–0.94 (0.02) | 50.5 | 0.133 | 0.52 | 0.60 | 0.38 | 0.76 | |
| Allelic model | 463 / 479 | 0.66 | 0.54–0.81 (< 0.001) | 0.0 | 0.549 | 0.52 | 0.60 | 0.80 | 0.57 | |
| bb vs. BB | 463 / 479 | 0.52 | 0.34–0.80 (0.003) | 0.0 | 0.876 | 0.52 | 0.60 | 0.06 | 0.96 | |
| Bb vs. BB | 463 / 479 | 0.66 | 0.41–1.05 (0.08) | 13.2 | 0.316 | 0.52 | 0.60 | 1.56 | 0.36 | |
| African | Dominant model | 230 / 226 | 2.41 | 0.63–9.18 (0.19) | 81 | 0.065 | −0.52 | 0.60 | −0.15 | 0.90 |
| Recessive model | 230 / 226 | 0.99 | 0.52–1.89 (0.96) | 26.8 | 0.242 | −1 | 0.31 | 0.18 | 0.23 | |
| Allelic model | 230 / 226 | 1.63 | 0.65–4.08 (0.29) | 86.3 | 0.031 | −0.52 | 0.60 | 0.05 | 0.96 | |
| bb vs. BB | 230 / 226 | 1.18 | 0.26–5.25 (0.83) | 67.0 | 0.082 | −1 | 0.31 | 0.15 | 0.35 | |
| Bb vs. BB | 230 / 226 | 2.40 | 0.81–7.17 (0.11) | 63.9 | 0.141 | −0.52 | 0.60 | −0.16 | 0.89 | |
| ApaI (rs7975232) | ||||||||||
| Overall | Dominant model | 2436 / 4074 | 1.03 | 0.82–1.29 (0.79) | 66.2 | < 0.001 | 0.25 | 0.80 | 0.62 | 0.54 |
| Recessive model | 2436 / 4074 | 1.03 | 0.90–1.17 (0.68) | 48.4 | 0.005 | 0.24 | 0.81 | 0.20 | 0.84 | |
| Allelic model | 2436 / 4074 | 1.05 | 0.90–1.23 (0.52) | 72.7 | < 0.001 | 0.99 | 0.32 | 0.98 | 0.34 | |
| aa vs. AA | 2436 / 4074 | 1.02 | 0.77–1.33 (0.90) | 52.9 | 0.002 | −0.18 | 0.85 | −0.56 | 0.57 | |
| Aa vs. AA | 2436 / 4074 | 0.91 | 0.80–1.04 (0.18) | 25.5 | 0.355 | −0.03 | 0.97 | 0.05 | 0.97 | |
| European | Dominant model | 1258/ 2913 | 0.91 | 0.70–1.18 (0.47) | 49.1 | 0.039 | −0.98 | 0.32 | −1.24 | 0.25 |
| Recessive model | 1258/ 2913 | 1.09 | 0.92–1.30 (0.32) | 56.9 | 0.013 | −0.63 | 0.53 | −0.28 | 0.78 | |
| Allelic model | 1258/ 2913 | 0.99 | 0.81–1.21 (0.90) | 68.6 | 0.001 | −1.16 | 0.24 | −0.62 | 0.54 | |
| aa vs. AA | 1258/ 2913 | 1.02 | 0.72–1.45 (0.91) | 53.1 | 0.024 | −1.70 | 0.08 | −1.03 | 0.33 | |
| Aa vs. AA | 1258/ 2913 | 0.90 | 0.75–1.09 (0.29) | 29.5 | 0.174 | −1.70 | 0.08 | −2.23 | 0.05 | |
| Asian | Dominant model | 1178 / 1161 | 1.27 | 0.78–2.05 (0.34) | 77.4 | < 0.001 | 1.70 | 0.08 | 0.90 | 0.39 |
| Recessive model | 1178 / 1161 | 0.91 | 0.71–1.15 (0.42) | 52.0 | 0.027 | 1.88 | 0.06 | 1.26 | 0.24 | |
| Allelic model | 1178 / 1161 | 1.15 | 0.82–1.62 (0.40) | 82.2 | < 0.001 | 1.34 | 0.18 | 1.69 | 0.13 | |
| aa vs. AA | 1178 / 1161 | 1.14 | 0.63–2.04 (0.66) | 64.8 | 0.002 | 1.34 | 0.18 | 0.23 | 0.82 | |
| Aa vs. AA | 1178 / 1161 | 0.92 | 0.72–1.18 (0.52) | 6.8 | 0.379 | 1.46 | 0.14 | 1.35 | 0.22 | |