Figure 4.

Cytokine levels in HUVECs in different culture conditions. (i) collagen solution (4800 mg/l), (ii) chitosan solution (1000 mg/l), (iii) collagen-chitosan mixed solution (1600 mg/l), (iv) AgNP solution (2.5 mg/l). Growth factors (a) VEGF, (b) EGF, (c) bFGF, (d) PDGF and (e) TGF-β1 were promoted by the collagen, chitosan and collagen-chitosan mixed solutions compared with the control. Inflammatory factors (f) TNF-α, (g) IL-1β, (h) IL-6, (i) IL-8 were inhibited by the collagen, chitosan and collagen-chitosan mixed solutions compared with the control. (a–i) The AgNP solution had no effect on the level of growth or inflammatory factors. *Compared with the control group, P < 0.05. ^#Compared with group A or B, P < 0.05