Table 2.

Patients with secondary clinical deterioration after stereotactic radiosurgery

New symptoms	Time after GK	Symptom occurring at recurrence?	Specific circumstances
Pituitary insufficiency	7 years	Yes	Incomplete treatment low-dose, pre-existing compressed chiasm
Periodic disorientation	7 years	Yes	Age 88 years; ARE after retreatment
Epileptic seizure	3 years	No	Died 8.5 years after RS, (unknown reason)
Recurrence and death	6 years	Yes	Meningiomatosis 4 resections 3 GK
Focal seizures, death	8 years	Yes	Died with 91 years
Tetraparesis due to tumour progression	3 years	Yes (out-of-field)	MIB index > 20%
Unilateral loss of hearing	3 years	Yes
Died with out-of-field recurrence	2 years	Yes (out-of-field)	Highly cellular multiple meningioma
Ophthalmoplegia	1.5 years	No	ARE (Patient died for unknown reasons)
Seizure	0.5 years	No	Multiple sclerosis