Table 2.
Baseline characteristics of 45 asymptomatic patients and 45 symptomatic controls treated for meningioma between 2004 and 2017
| Patient and tumor characteristics | Case (n = 45) | Control (n = 45) | p value |
|---|---|---|---|
| Female, n (%) | 31 (68.9) | 35 (77.8) | 0.48 |
| Karnofsky score > 70, n (%) | 41 (91.1) | 41 (91.1) | 1.0 |
| Predisposing factors* | 5 (11.1) | 1 (2.2) | 0.20 |
| Work status | 0.69 | ||
| Pension, n (%) | 15 (33.3) | 15 (33.3) | |
| Sick leave, n (%) | 3 (7.3) | 1 (2.2) | |
| Partial sick leave, n (%) | 3 (7.3) | 1 (2.2) | |
| Working full hours, n (%) | 19 (46.3) | 24 (57.1) | |
| Other, n (%) | 1 (2.2) | 1 (2.2) | |
| Missing, n (%) | 4 (9.8) | 3 (7.3) | |
| Main indication(s) of surgery** | < 0.001 | ||
| Symptoms, n (%) | 0 (0) | 45 (100) | |
| Growth, n (%) | 15 (34.9) | 4 (9.3) | |
| Size, n (%) | 10 (23.3) | 16 (37.2) | |
| Patient’s wish, n (%) | 11 (25.6) | 3 (7) | |
| Expected natural course of disease, n (%) | 4 (9.3) | 2 (4.7) | |
| Edema, n (%) | 3 (7) | 2 (4.7) | |
| Unknown, n (%) | 2 (4.7) | 2 (4.7) | |
| Preoperative embolization, n (%) | 2 (4.4) | 3 (6.7) | 1.0 |
| Preoperative AED, n (%) | 0 (0) | 16 (35.5) | < 0.001 |
| Contact or invasion of venous sinus, n (%) | 16 (35.6) | 20 (44.4) | 0.74 |
| Mainly left-sided tumor, n (%) | 26 (57.8) | 23 (51.1) | 0.53 |
| Both sides (if multiple resected at the same time), n (%) | 1 (2.2) | 0 (0) | |
| Largest diameter at diagnosis in mm, mean (SD) | 27.8 (12.8) | 46.3 (15.3) | < 0.001 |
| Tumor volume (cm3) at diagnosis, median (Q1–Q3) | 9.3 (5.3–22.2) | 35.7 (15.5–61.5) | < 0.001 |
| Tumor volume (cm3) at surgery, median (Q1–Q3), n = 19 | 10.7 (5.7–21.2)*** | N.A**** | |
| Solitary meningioma, n (%) | 42 (93.3) | 42 (93.3) | 1.0 |
| Edema, n (%) | 18 (40.0) | 30 (66.7) | 0.02 |
| Calcification, n (%) | 8 (17.8) | 10 (22.2) | 0.79 |
| Hyperintensity on T2, n (%) | 6 (13.3) | 7 (15.6) | 1.0 |
*Brain irradiation and genetic mutations such as NF2
**May exceed 100% since several indications for surgery may co-exist
***Not all cases had several MRI before surgery
****Too few controls had follow-up MRI before surgery due to short time from diagnosis to surgery