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Melatonin altered intestinal morphology and promoted the gut leak in DSS rats. (a) Melatonin influenced intestinal morphology. (b) The histology score of DSS and MT rats. (c) Melatonin had no significant effect to prevent LPS production in the plasma. (d–f) Effects of melatonin in regulating zonulin, IL-1β, and TNF-α in the colon. Data represent the mean ± SEM. ∗p < 0.05; ∗∗p < 0.01. CON = 7; DSS = 5; MT = 6.
