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. 2020 Aug 7;11:3959. doi: 10.1038/s41467-020-17794-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a This figure provides the unadjusted Odds Ratios (ORs, point) and 95% CIs for autism in transgender and gender-diverse individuals compared to either cisgender males, cisgender females, or cisgender (cisgender males and cisgender females) individuals in five datasets (C4: N = 514,100; MU: N = 85,670; APHS: N = 2312; IMAGE: N = 1803; and LifeLines: N = 37,975). b This figure provides adjusted ORs (point) and 95% CIs for autism in transgender and gender-diverse individuals compared to cisgender males, cisgender females, or all cisgender individuals in five datasets (C4: N = 514,100; MU: N = 85,670; APHS: N = 2312; IMAGE: N = 1803; and LifeLines: N = 37,975). ORs have been adjusted for age, educational attainment, and in the case of IMAGE dataset, an additional dummy variable for study (see “Supplementary Methods”). The y-axis is on the same scale for both the panels. The differences in ORs for the IMAGE dataset between Models 1 and 2 is primarily due to the inclusion of “study” group as a covariate. Specifically, the IMAGE dataset consists of individuals recruited into a study of mathematics and autism (“Methods”). Whilst the mathematics group is predominantly male and have higher educational attainment (all have at least an undergraduate degree), the case–control group had a more balanced ratio and a wider range of educational attainment. Covarying for the study the participants have been recruited into (mathematics or autism case–control) changes the ORs.