Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 7;10:13414. doi: 10.1038/s41598-020-69660-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of caffeine (15 mg/kg, i.p.) in wild type and forebrain A_2AR KO mice on motor behavior (A), ergospirometry (B–E), and thermoregulation (F, G) of male mice. (A) Caffeine displayed a psychostimulant effect in the open field in wild type mice, but not in forebrain-A_2AR KO mice. Ergospirometry increased V̇O₂ (B), running power (B), and metabolic rate (E) until the animals reached fatigue. The dotted line represents the V̇O₂max of the wild type-saline group (B). Caffeine increased V̇O₂max (C) and running power (D) of wild type, but not forebrain A_2AR KO mice. Resting core (F) and tail (G) temperature and tail heating (G') were similar between groups. Data are presented as mean ± SEM. N = 8–9 animals/group for 12 independent experiments. *P < 0.05 vs. saline and ^#P < 0.05 vs. caffeine (Two-way ANOVA followed by Newman-Keuls post hoc test). A_2AR adenosine A_2A receptor, fb forebrain, KO knockout, Rec recovery, RER respiratory exchange ratio. V̇O₂ oxygen consumption.