Fig. 2.

Baseline serum levels of adiponectin and MACCE at 3-year follow-up. a Serum levels of adiponectin in patients with MACCE and free-MACCE. b Multivariate analyses for MACCE according to adiponectin quartiles. Adjustments for age, sex (female vs. male), obese (yes vs. no), diabetes mellitus (yes vs. no), atrial fibrillation (yes vs. no), previous CVD events (yes vs. no), NHISS, stroke syndrome (TACS vs. other), stroke subtype (Cardioembolic vs. other), acute treatment (no vs. yes), serum levels of glucose, CRP, eGFR, copeptin and NT-ProBNP. c ROC curves were utilized to evaluate the accuracy of serum level of adiponectin to predict MACCE. d The Kaplan–Meier estimates of MACCE stratified by baseline adiponectin quartiles. Adiponectin quartiles were defined as Q1 < 4.8 μg/mL, Q2 4.8–7.1 μg/mL, Q3 7.2–9.8 μg/mL and Q4 > 9.8 μg/mL. MACCE was defined as CVD death, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization by percutaneous coronary intervention or coronary artery bypass grafting. HR Hazard ratio, CI confidence interval, BMI body mass index, NIHSS National Institutes of Health Stroke Scale, CRP C-reactive protein, NT-proBNP N-terminal fragment of precursor of B-type natriuretic peptide, TACS total anterior circulation syndrome, GFR glomerular filtration rate, CVD cardiovascular disease, MACCE major adverse cardiovascular and cerebrovascular events