Table 2:
Risk of SPMN according to the characteristics of the index cancer, stratified by sex, SEER 2000–2015.
| Men | Women | |||||
|---|---|---|---|---|---|---|
| Observed SPMN | SIR (95 % CI) | EAR per 10000 PYR | Observed SPMN | SIR (95 % CI) | EAR per 10000 PYR | |
| Age at diagnosis of index malignancy, y | ||||||
| < 49 | 424 | 2.65 (2.40, 2.91) | 75.32 | 1,270 | 1.86 (1.76, 1.97) | 31.96 |
| 50–59 | 1,333 | 1.90 (1.80, 2.00) | 100.86 | 1,149 | 1.86 (1.75, 1.97) | 76.09 |
| 60–69 | 1,312 | 1.58 (1.50, 1.67) | 120.35 | 1,042 | 1.67 (1.57, 1.77) | 93.82 |
| 70+ | 661 | 1.35 (1.25, 1.46) | 101.70 | 1,031 | 1.56 (1.47, 1.66) | 103.09 |
| Race | ||||||
| White | 3,266 | 1.68 (1.62, 1.74) | 96.04 | 3,577 | 1.69 (1.64, 1.75) | 55.47 |
| Black | 361 | 2.06 (1.86, 2.29) | 169.34 | 634 | 2.10 (1.94, 2.27) | 82.10 |
| Other | 100 | 2.13 (1.74, 2.59) | 104.48 | 277 | 1.82 (1.61, 2.04) | 47.18 |
| Marital status at diagnosis of index malignancy | ||||||
| Married | 2,276 | 1.61 (1.54, 1.67) | 86.80 | 1,915 | 1.68 (1.61, 1.76) | 48.80 |
| Divorced/separated/widowed | 675 | 1.84 (1.71, 1.99) | 130.36 | 1,430 | 1.73 (1.65, 1.83) | 79.58 |
| Never married | 605 | 2.08 (1.92, 2.26) | 129.68 | 873 | 1.90 (1.77, 2.03) | 52.45 |
| Unknown | 174 | 1.62 (1.39, 1.88) | 87.43 | 274 | 1.72 (1.53, 1.94) | 55.79 |
| Year of diagnosis of index malignancy | ||||||
| 2000–2004 | 1,440 | 1.65 (1.57, 1.74) | 96.26 | 2,002 | 1.52 (1.45, 1.58) | 40.10 |
| 2005–2009 | 1,400 | 1.72 (1.63, 1.81) | 98.76 | 1,589 | 1.86 (1.77, 1.95) | 65.65 |
| 2010+ | 643 | 1.79 (1.65, 1.93) | 106.36 | 651 | 2.25 (2.08, 2.43) | 97.81 |
| Grade of index malignancy | ||||||
| Well | 257 | 1.74 (1.53, 1.96) | 122.26 | 603 | 1.89 (1.74, 2.05) | 70.41 |
| Moderate | 1,312 | 1.88 (1.78, 1.99) | 121.86 | 1,545 | 1.90 (1.80, 2.00) | 71.61 |
| Poor | 1,363 | 1.59 (1.51, 1.68) | 83.22 | 1,124 | 1.66 (1.56, 1.75) | 53.68 |
| Undifferentiated/unknown | 798 | 1.66 (1.54, 1.78) | 92.87 | 1,214 | 1.58 (1.49, 1.67) | 41.33 |
| Stage of index malignancy | ||||||
| Localized | 695 | 1.74 (1.61, 1.87) | 119.58 | 2,172 | 1.61 (1.55, 1.68) | 42.46 |
| Regional | 2,400 | 1.63 (1.57. 1.70) | 86.41 | 1,846 | 1.85 (1.77, 1.94) | 76.25 |
| Distant | 512 | 2.12 (1.94, 2.31) | 154.75 | 270 | 1.98 (1.75, 2.23) | 86.35 |
| Unknown/unstaged | 123 | 1.80 (1.50, 2.15) | 111.74 | 202 | 1.95 (1.69, 2.24) | 77.72 |
SPMN = Second primary malignant neoplasm; SEER = Surveillance, Epidemiology, and End Results; SIR = Standardized incidence ratio; EAR = Excess absolute risk; PYR = Person-year at risk; CI = Confidence interval; HPV = Human papillomavirus.