Table 6.
Risk of SPMN according to latency interval and year of diagnosis, stratified by sex, SEER 2000–2015.
| SIR (95 % Confidence Interval) | |||||||
|---|---|---|---|---|---|---|---|
| Latency interval | Year of diagnosis | ||||||
| Index P-HPV-AC | < 1year | 1–5 year | 5–10 year | 10+ year | 2000–2004 | 2005–2009 | 2010–2015 |
| Overall | |||||||
| All index P-HPV-AC | 1.93 (1.83, 2.04) | 1.81 (1.75, 1.87) | 1.59 (1.52, 1.65) | 1.44 (1.34, 1.56) | 1.57 (1.52, 1.63) | 1.79 (1.73, 1.85) | 1.99 (1.90, 2.08) |
| Both men and women | |||||||
| Oropharynx | 1.85 (1.71, 2.00) | 1.93 (1.84, 2.01) | 1.72 (1.62, 1.83) | 1.60 (1.42, 1.80) | 1.79 (1.70, 1.88) | 1.85 (1.75, 1.94) | 1.89 (1.77, 2.01) |
| Anal | 1.10 (0.65, 1.74) | 1.48 (1.15, 1.87) | 1.50 (1.09, 2.03) | 0.82 (0.33, 1.70) | 1.06 (0.78, 1.41) | 1.45 (1.08, 1.90) | 1.91 (1.36, 2.61) |
| Men | |||||||
| Oropharynx | 1.76 (1.62, 1.92) | 1.86 (1.77, 1.95) | 1.67 (1.56, 1.78) | 1.51 (1.32, 1.72) | 1.73 (1.63, 1.82) | 1.76 (1.66, 1.86) | 1.82 (1.70, 1.95) |
| Anal | 0.89 (0.29, 2.09) | 1.14 (0.66, 1.82) | 1.34 (0.64, 2.47) | 1.34 (0.27, 3.91) | 1.18 (0.66, 1.95) | 1.36 (0.78, 2.22) | 1.33 (0.61, 2.52) |
| Penile | 1.60 (1.24, 2.02) | 1.39 (1.19, 1.62) | 1.34 (1.07, 1.64) | 1.41 (0.94, 2.02) | 1.28 (1.09, 1.49) | 1.45 (1.20, 1.72) | 1.72 (1.36, 2.15) |
| Women | |||||||
| Oropharynx | 2.36 (1.96, 2.82) | 2.39 (2.14, 2.65) | 2.10 (1.79, 2.44) | 2.22 (1.66, 2.92) | 2.14 (1.89, 2.41) | 2.42 (2.13, 2.73) | 2.36 (2.00, 2.77) |
| Anal | 1.21 (0.64, 2.06) | 1.64 (1.23, 2.15) | 1.39 (0.92, 2.01) | 0.64 (0.17, 1.64) | 1.01 (0.69, 1.43) | 1.49 (1.01, 2.06) | 2.20 (1.48, 3.14) |
| Cervical | 2.21 (2.02, 2.42) | 1.54 (1.45, 1.64) | 1.28 (1.19, 1.39) | 1.17 (1.03, 1.32) | 1.34 (1.27, 1.42) | 1.55 (1.45, 1.66) | 2.00 (1.82, 2.19) |
| Vulvar | 1.86 (1.56, 2.19) | 2.40 (2.20, 2.62) | 2.37 (2.11, 2.66) | 2.28 (1.83, 2.82) | 1.95 (1.77, 2.14) | 2.56 (2.32, 2.83) | 2.68 (2.34, 3.05) |
| Vaginal | 2.17 (1.51, 3.02) | 1.85 (1.46, 2.32) | 1.44 (1.00, 2.02) | 2.47 (1.46, 3.90) | 1.58 (1.24, 2.01) | 2.19 (1.68, 2.79) | 1.96 (1.33, 2.78) |
SPMN = Second primary malignant neoplasm; SEER = Surveillance, Epidemiology, and End Results; SIR = Standardized incidence ratio; EAR = Excess absolute risk per 10000 person-year at risk; CI = Confidence interval; P-HPV-AC = Potentially human papillomavirus associated cancers.