Table 2.

Association Analysis of HLA Alleles in the Comparison of Patients with AS with AAU versus Patients with AS without AAU

HLA Allele#	Position*	OR	95% CI	P Value
HLA-B*27	31431272	2.35	2.08-2.66	1.86 × 10−42
HLA-B*2705	31431272	2.27	2.02-2.56	1.49 × 10−41
HLA-C*02	31346171	1.33	1.21-1.45	3.37 × 10−9
HLA-C*0202	31346171	1.33	1.21-1.45	3.37 × 10−9
HLA-C*01	31346171	1.25	1.14-1.38	4.26 × 10−6
HLA-C*0102	31346171	1.25	1.14-1.38	4.26 × 10−6
HLA-DRB1*0103	32660042	1.34	1.14-1.57	0.00044
HLA-DRB1*1501	32660042	1.23	1.09-1.39	0.00074
HLA-C*0701	31346171	0.82	0.72-0.92	0.00078
HLA-B*4402	31431272	0.79	0.68-0.91	0.0011
HLA-C*05	31346171	0.80	0.70-0.91	0.0011
HLA-C*0501	31346171	0.80	0.70-0.91	0.0011
HLA-DQB1*0602	32739039	1.22	1.08-1.38	0.0018
HLA-DRB1*15	32660042	1.21	1.07-1.37	0.0018
HLA-B*08	31431272	0.81	0.71-0.93	0.0023
HLA-B*0801	31431272	0.81	0.71-0.93	0.0023
HLA-B*44	31431272	0.84	0.75-0.95	0.0051
Adjusting for the HLA-B*27 allele
HLA-DRB1*15	32660042	1.28	1.13-1.45	8.14 × 10−5
HLA-B*07	31431272	1.30	1.13-1.50	0.00023
HLA-DPB1*03	33157346	1.16	1.04-1.29	0.0088
Adjusting for both HLA-B*27 and HLA-DRB1*15 allele
HLA-DPB1*03	33157346	1.17	1.05-1.31	0.0048

OR, odds ratio; 95% CI, 95% confidence interval.

^*UCSC, human genome build 19.

^#HLA allele is imputed using SNP2HLA.