Table.

Single-Variant Association of Rare CFI Variants in the Southampton AMD Cohort

Rare CFI Variant	Cases, n	Controls, n	P Value
G119R	7	1	0.0296
K441R	4	2	0.4283
P553S	2	3	1
G261D	6	15	0.1214

Single-variant association studies were performed using GraphPad prism v7, with a 2 × 2 contingency table, Fisher's exact test, and a two-tailed P value. The association between AMD incidence and the four rare CFI variants recurring five or more times in the Southampton cohort, as per the SNP-chip sequencing only, is displayed here. Only the G119R variant reached statistical significance (P = 0.0296), which was defined as *P < 0.05.