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Metformin corrects circadian rhythm in db/db mice. (A) Representative actograms show the wheel-running activity of db/m and db/db mice under regular light and dark conditions. (B) Bar chart shows the total wheel-running activity of db/m mice (n = 61), db/db mice (n = 42), and metformin-treated db/db mice (n = 55). ****P < 0.0001 (Brown–Forsythe and Welch ANOVA test followed by unpaired t-test).
