Fig. 1.

Conceptual scenario model of excessive DAMPs emission that may avalanche-like develop into a chain of five lines of different DAMPs, promoting and expanding acute local/systemic hyperinflammatory responses. Clinically, these processes manifest as acute solid organ failure and/or systemic inflammatory response syndrome, which may lead to multiple organ dysfunction syndrome. aiic activated innate immune cells, cDAMPs constitutive DAMPs, HMGB1 high mobility group box 1, iDAMPs inducible DAMPs, IFN interferon, MODS multiple organ dysfunction syndrome, mtDNA mitochondrial DNA, RN regulated necrosis, stress resp stress responses, SIRS systemic inflammatory response syndrome, TNF tumor necrosis factor, TXNIP thioredoxin-interacting protein.

Source: The figure was published in Land (2018)