Fig. 4.
This figure is the continuation of Fig. 3 and shows the second part of key events resulting in homeostasis, whereby two phases of events (MIE and KE4→n) are depicted again. Thus, the fourth inflammatory event proceeds to SAMP-driven resolution of inflammation (KE5–n), associated with MAMP/DAMP-promoted induction of an innate immune memory (KE6–n), finally resulting in homeostasis. DAMPs damage-associated molecular patterns, HO homeostasis, KE key event, KER key event relationship, MAMPs microbe-associated molecular patterns, MIE molecular initiating event, PMNs polymorphonuclear neutrophils, PRMs pattern recognition molecules, SAMPs suppressing DAMPs.
Sources: Smith et al. (2015), Escher et al. (2017), Leist et al. (2017) and Vinken et al. (2017)