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. 2020 Aug 4;11(31):2959–2972. doi: 10.18632/oncotarget.27426

Figure 5. TQ reduces tumor growth in NOD-SCID and NOG mice.

Figure 5

(A, B) NOD-SCID mice (8 mice/group) (A) were injected with 100 5FU-sensitive HCT116 G1 spheres and NOG mice (5 mice/group) (B) were injected with 250 5FU-resistant HCT116 G1 spheres and tumor progression was monitored. Tumor volume during 21 days of i. p. treatment (3×/week) with either 20 mg/kg TQ or 10% methanol in physiologic saline was reported. P < 0.05 between TQ and vehicle (control) treated animals. Representative images of control and TQ-treated mice at day 21 and H&E stain of tumor tissues are shown. (C, D) Average tumor volume of control and TQ treated mice (n = 3) during and after stopping treatment for 2 weeks was monitored in NOD-SCID and NOG mice and showed an increase in volume that was still significantly different from control untreated group.