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. 2020 Jul 30;16(14):2675–2691. doi: 10.7150/ijbs.46627

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The structure domain of PTEN-induced putative kinase 1 (PINK1) and Parkin. (A) PINK1 possesses an N-terminal mitochondrial targeting sequence (MTS), an α-helical transmembrane (TM) segment, and a Ser/Thr kinase domain (Kinase). (B) Parkin contains an N-terminal ubiquitin-like (UBL) domain, three really interesting new gene (RING) domains (RING0, RING1, and RING2), and an in-between RING (IBR) domain between RING1 and RING2. PINK1 directly activates Parkin by phosphorylated Serine 65 (Ser65) in the UBL domain of Parkin.