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. 2020 Jul 19;16(14):2595–2611. doi: 10.7150/ijbs.45886

Figure 1.

Figure 1

Effect of chidamide on the primary resistance of ALK mutation-free NSCLC cells to crizotinib. NSCLC cells were treated with various concentrations of crizotinib (CRI) alone or combined with chidamide (CHI) at ≤1/4 IC50 for 72 hr. Cell viability was measured by using the IncuCyte platform (top charts). The crizotinib-IC50 values for 12 NSCLC cell lines were calculated in the absence or presence of chidamide, and the fold change of crizotinib-IC50 in three independent experiments is presented as a histogram (bottom right charts). The synergetic effect of chidamide-crizotinib cotreatment on cell proliferation inhibition was calculated using the CI equation and presented as Fa (fraction affected by the dose) in the Fa-CI plots (bottom left charts). */**/***, p<0.05/0.0/0.001; ns, not significant; (A) HCC827; (B) H661; (C) Calu-3; (D) H1299; (E) H358; (F) H596; (G) H460; (H) A549; (I) H1975; (J) H1650; (K) H292; (L) H1395.