Table 2.
Multivariate Cox proportional-hazards analysis in the overall HCC patients
| Variable | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (<50 y vs. ≥50 y) | 0.995 | 0.628-1.578 | 0.985 | 0.914 | 0.531-1.573 | 0.746 |
| Gender (Male vs. Female) | 2.254 | 0.648-7.835 | 0.201 | 1.905 | 0.405-8.965 | 0.415 |
| Tumor size (<5cm vs. ≥5cm) | 2.689 | 1.325-5.460 | 0.006 | 2.783 | 1.284-6.034 | 0.010 |
| Tumor multiplicity (Single vs. Multiple) | 1.430 | 0.833-2.455 | 0.195 | 1.726 | 0.944-3.157 | 0.076 |
| HBV infection (Negative vs. Positive) | 1.538 | 0.500-4.728 | 0.452 | 0.904 | 0.231-3.542 | 0.884 |
| Liver cirrhosis (Negative vs. Positive) | 0.894 | 0.455-1.756 | 0.745 | 1.286 | 0.526-3.142 | 0.582 |
| Histological grade (Poor and Moderate vs. Well) | 0.733 | 0.337-1.593 | 0.433 | 0.474 | 0.164-1.371 | 0.168 |
| Vascular invasion (Negative vs. Positive) | 1.438 | 0.783-2.640 | 0.242 | 1.623 | 0.831-3.169 | 0.156 |
| TNM stage (Ⅰ+Ⅱ vs. Ⅲ+Ⅳ) | 0.575 | 0.262-1.263 | 0.168 | 0.795 | 0.324-1.956 | 0.618 |
| Serum AFP (<400ug/L vs. ≥400 μg/L) | 1.348 | 0.856-2.124 | 0.198 | 1.025 | 0.595-1.768 | 0.928 |
| Density of H-CAFs (Low vs. Moderate and High) | 2.348 | 1.259-4.380 | 0.007 | 2.318 | 1.027-5.232 | 0.043 |