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Summary of Results from Dose Proportionality Test for Two Pharmacokinetic Parameters
| Parameter | Dose Range Studied (mg) | Slope (95%CI for Slope) |
|---|---|---|
| AUClast (ng·h/mL) | 35–600 | 1.310 (1.185–1.436) |
| Cmax (ng/mL) | 35–600 | 1.104 (1.023–1.185) |
| 75–600 | 1.026 (0.917–1.135) |
Abbreviations: AUClast, area under the plasma concentration-time curve from time 0 to last measurable time point; Cmax, measured maximum plasma concentration.
